Selected project
D014D11
Graphics
Graphic caption: Flow Cytometry: B cells/B220+MHCclassII+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD4+/CD62L+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD4+/CD62L+ vs. CD45+/CD3+CD4+ scatterplot
Graphic caption: Flow Cytometry: CD3+CD8+/CD62L+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD8+/CD62L+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: CD45+/B cells boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/B cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD11b+Gr1+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD8+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/CD3+gammadeltaTCR+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/T cells boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/B cells scatterplot
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Flow Cytometry: NK+/CD11b+ boxplot with stripchart, split by sex and genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of female mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of male mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Ig G1 / Ig G2b boxplot with stripchart, split by sex and genotype
Graphic caption: Immunglobulins: Ig G1 boxplot, split by sex and genotype including out of range measurements (OOR)
Graphic caption: Immunglobulins: Ig G2b boxplot, split by sex and genotype including out of range measurements (OOR)
Graphic caption: Immunglobulins: Ig G3 boxplot, split by sex and genotype including out of range measurements (OOR)
Graphic caption: Monocyte gating: Monocyte pie chart, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=10n=10n=10n=10   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 34.41 ± 9.2233.69 ± 4.5630.88 ± 3.0430.97 ± 5.020.8670.1040.83
CD45+/CD3+CD4+ 22.39 ± 6.3319.9 ± 3.3820.45 ± 3.2518.55 ± 3.590.1180.2370.831
CD45+/CD3+CD8+ 9.82 ± 2.9511.24 ± 1.558.38 ± 1.4610.43 ± 1.950.0120.0930.63
CD45+/B cells 30.93 ± 7.2731.07 ± 4.6932.26 ± 4.4927.93 ± 6.910.2750.6350.245
CD45+/CD5-NK+ 6.67 ± 1.577.58 ± 4.37.26 ± 3.565.76 ± 1.80.760.5280.218
CD45+/CD11b+Gr1+ 13.95 ± 3.8810.88 ± 2.7812.61 ± 4.5919.18 ± 4.10.1630.008< 0.001
CD45+/NK-Gr1-CD11b+ 8.15 ± 1.998.43 ± 2.7110.57 ± 410.9 ± 3.350.7560.0180.984
CD3+CD4+/CD25+ 4.07 ± 1.393.69 ± 0.884.09 ± 1.593.35 ± 0.690.1490.6650.635
CD45+/CD3+gammadeltaTCR+ 0.69 ± 0.160.85 ± 0.130.57 ± 0.180.64 ± 0.120.0210.0010.328
CD3+CD4+/CD62L+ 58.38 ± 16.0370.9 ± 9.2758.62 ± 11.3765.13 ± 13.740.0250.5010.464
CD3+CD4+/CD44+ 94.03 ± 3.5592.74 ± 4.0791.86 ± 4.6892.31 ± 4.830.760.3470.528
CD3+CD8+/CD62L+ 72.97 ± 12.4982.09 ± 6.8274.01 ± 9.979.08 ± 8.170.0250.7470.508
CD3+CD8+/CD44+ 90.64 ± 5.6687.56 ± 5.3987.48 ± 5.9684.94 ± 8.90.1890.1770.898
CD45+/CD5+NK+ 0.5 ± 0.120.41 ± 0.120.39 ± 0.150.45 ± 0.20.7490.5440.125
B cells/IgD+ 77.47 ± 4.9678.78 ± 9.7285.4 ± 3.6385.14 ± 3.780.7860.0010.684
B cells/CD5+ 4 ± 0.723.82 ± 0.922.58 ± 0.592.54 ± 0.890.668< 0.0010.76
B cells/B220+MHCclassII+ 93.75 ± 1.4491.64 ± 2.3396.21 ± 0.8591.89 ± 3.34< 0.0010.0590.121
NK+/CD11b+ 92.43 ± 2.6284.53 ± 6.3390.26 ± 3.6679.05 ± 4.99< 0.0010.0130.265
CD3+ rest 2.19 ± 0.472.55 ± 0.722.05 ± 0.391.99 ± 0.290.3440.0290.191
CD45+/CD3+CD4+CD25+ 0.87 ± 0.20.73 ± 0.210.81 ± 0.230.61 ± 0.130.010.1520.625
ratio CD4:CD8 2.32 ± 0.351.78 ± 0.282.54 ± 0.771.81 ± 0.35< 0.0010.410.517
ratio Granulocytes:(Tcells+B cells) 0.22 ± 0.070.17 ± 0.040.2 ± 0.080.33 ± 0.090.1030.0030.001
ratio Tcells:Bcells 1.24 ± 0.651.12 ± 0.320.97 ± 0.151.22 ± 0.530.6560.5430.222
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=10n=10n=10n=10   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 31.65
[30.75 , 39.3]
33.45
[30.75 , 36.7]
31.25
[29.8 , 32.02]
30.15
[27.98 , 31.52]
0.9120.5660.92
CD45+/CD3+CD4+ 20.25
[18.5 , 26.35]
20.3
[17.1 , 22.77]
21.5
[20.18 , 22.65]
18.1
[16.15 , 19.9]
0.5290.2390.203
CD45+/CD3+CD8+ 9.46
[8.66 , 11]
11.2
[10.19 , 11.72]
8.69
[7.69 , 9.41]
10.25
[9.05 , 11.95]
0.0890.0350.004
CD45+/B cells 30.65
[25.43 , 35.75]
30.05
[29.38 , 33.23]
32.7
[29.45 , 34.88]
27.45
[23.93 , 33.33]
0.9120.1650.289
CD45+/CD5-NK+ 6.48
[6.29 , 7.31]
8.29
[4.21 , 9.08]
7.64
[5.12 , 10.36]
5.55
[4.36 , 7.04]
0.5790.3150.457
CD45+/CD11b+Gr1+ 13.45
[12.03 , 16.35]
10.15
[9.7 , 12.47]
12.35
[9.94 , 14.97]
18.3
[17.55 , 19.32]
0.0710.0090.402
CD45+/NK-Gr1-CD11b+ 8.42
[6.73 , 9.71]
8.07
[7.06 , 9.56]
9.48
[8.29 , 10.95]
10.19
[8.39 , 11.1]
0.9710.7820.723
CD3+CD4+/CD25+ 3.5
[3.13 , 4.53]
3.41
[3.01 , 4.13]
3.9
[3.56 , 4.57]
3.42
[2.93 , 3.88]
0.4940.190.144
CD45+/CD3+gammadeltaTCR+ 0.74
[0.53 , 0.77]
0.87
[0.79 , 0.92]
0.54
[0.44 , 0.69]
0.62
[0.58 , 0.66]
0.0190.1840.032
CD3+CD4+/CD62L+ 64.4
[45.85 , 69.17]
70.25
[68.12 , 75.55]
60.95
[51.62 , 67.65]
67.15
[64.8 , 71.3]
0.0750.1010.019
CD3+CD4+/CD44+ 94.95
[91.72 , 96.47]
93.6
[92.35 , 94.72]
92.6
[90.72 , 94.12]
93.35
[88.2 , 96.53]
0.4470.6990.92
CD3+CD8+/CD62L+ 79.1
[66.22 , 81.3]
83.55
[78.1 , 86.33]
75.55
[72.03 , 80.33]
81.95
[75.78 , 85.15]
0.0720.1590.024
CD3+CD8+/CD44+ 92.05
[86.53 , 94.85]
88.75
[85.7 , 91.67]
88.05
[85.55 , 92.47]
88.15
[77.12 , 91.5]
0.1480.7390.224
CD45+/CD5+NK+ 0.48
[0.42 , 0.54]
0.38
[0.34 , 0.45]
0.38
[0.25 , 0.54]
0.46
[0.32 , 0.56]
0.060.6170.569
B cells/IgD+ 77.9
[74.58 , 80.33]
80.1
[72.97 , 85.12]
85.15
[83.38 , 88.78]
85.45
[83.12 , 88.5]
0.5910.9280.49
B cells/CD5+ 3.87
[3.44 , 4.45]
3.84
[3.25 , 4.13]
2.42
[2.19 , 2.75]
2.34
[1.91 , 2.98]
0.5790.7810.773
B cells/B220+MHCclassII+ 94.1
[92.5 , 94.78]
92
[90.22 , 93.42]
96.2
[95.83 , 96.58]
91.45
[89.67 , 94.72]
0.0270.002< 0.001
NK+/CD11b+ 92
[91.28 , 94.4]
85.2
[81.22 , 89.47]
91.6
[87.62 , 92.97]
78.45
[76.78 , 80.45]
0.001< 0.001< 0.001
CD3+ rest 2.29
[2.05 , 2.49]
2.26
[2.12 , 2.96]
2.06
[1.7 , 2.24]
2.06
[1.75 , 2.22]
0.6440.810.846
CD45+/CD3+CD4+CD25+ 0.87
[0.77 , 1.03]
0.66
[0.6 , 0.75]
0.82
[0.79 , 0.97]
0.57
[0.51 , 0.69]
0.1050.0410.006
ratio CD4:CD8 2.25
[2.1 , 2.56]
1.7
[1.56 , 1.98]
2.31
[2.21 , 2.92]
1.72
[1.61 , 1.94]
0.0020.015< 0.001
ratio Granulocytes:(Tcells+B cells) 0.2
[0.17 , 0.25]
0.16
[0.15 , 0.19]
0.18
[0.17 , 0.26]
0.31
[0.29 , 0.35]
0.0920.0070.401
ratio Tcells:Bcells 1.04
[0.87 , 1.54]
1.11
[0.91 , 1.25]
0.94
[0.88 , 1.08]
1.04
[0.86 , 1.27]
0.8380.5910.473
Media files
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