Selected project
Exph5 / EPD0329_1_G11-tm1b
Graphics
Graphic caption: SHIRPA: Locomotor Activity boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Grip strength: Mean force (2 and 4 paws) boxplot, split by sex and genotype
Graphic:
Graphic caption: Grip strength: Mean force (2 and 4 paws) scatterplot, split by sex and genotype
Graphic:
Graphic caption: ABR: Average plot, split by sex and genotype. Values above measurement limit (85db) are replaced by 100.
Graphic:
Tables
Table caption: SHIRPA: Locomotor activity and body mass (SHIRPA): Means, standard deviation and p-values calculated by a linear model
Table:
female
male
linear model
linear model
linear model
con
mut
con
mut
genotype
sex
genotype:sex
n=9
n=5
n=9
n=8
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Weight
21.02 ± 1.08
21.1 ± 1.2
23.87 ± 1.38
24.26 ± 1.23
0.607
< 0.001
0.729
Locomotor Activity
20.56 ± 5.15
21 ± 4.53
15 ± 8.03
15.75 ± 8.41
0.818
0.045
0.953
Table caption: SHIRPA: Results ($^{1}$ Fisher's Exact test)
Table:
female
male
both
con
mut
con
mut
con
mut
p value
1
n=9
n=5
n=9
n=8
58.1%
41.9%
Absolute
Absolute
Percent
Limb Grasping
1
Absent
9
5
9
8
100%
100%
Present
0
0
0
0
0%
0%
Pinna Reflex
1
Present
9
5
9
8
100%
100%
Absent
0
0
0
0
0%
0%
Contact Righting Reflex
1
Present
9
5
9
8
100%
100%
Absent
0
0
0
0
0%
0%
Evidence Of Biting
1
No aggression
9
5
9
8
100%
100%
Aggressive
0
0
0
0
0%
0%
Vocalisation
1
No
9
5
9
8
100%
100%
Yes
0
0
0
0
0%
0%
Unexpected Behaviors
1
None
9
5
9
8
100%
100%
Circling
0
0
0
0
0%
0%
Jumping
0
0
0
0
0%
0%
Retropulsion
0
0
0
0
0%
0%
Other
0
0
0
0
0%
0%
Head Bobbing
1
Absent
9
5
9
8
100%
100%
Present
0
0
0
0
0%
0%
Table caption: SHIRPA: Results ($^{1}$ Fisher's Exact test)
Table:
female
male
both
con
mut
con
mut
con
mut
p value
1
n=9
n=5
n=9
n=8
58.1%
41.9%
Absolute
Absolute
Percent
Body Position
1
Inactive
0
0
0
0
0%
0%
Active
9
5
9
8
100%
100%
Excessively Active
0
0
0
0
0%
0%
Tremor
1
Absent
9
5
9
8
100%
100%
Present
0
0
0
0
0%
0%
Defecation
0.676
Present
7
4
8
6
83.3%
76.9%
Absent
2
1
1
2
16.7%
23.1%
Transfer Arousal
1
Prolongued freeze
0
0
0
0
0%
0%
Brief freeze
9
5
9
8
100%
100%
Immediate movement
0
0
0
0
0%
0%
Gait
1
Fluid
9
5
9
8
100%
100%
Abnormal
0
0
0
0
0%
0%
Tail Elevation
1
Dragging
0
0
0
0
0%
0%
Horizontal
9
5
9
8
100%
100%
Elevated
0
0
0
0
0%
0%
Startle Response
1
No reaction
0
0
0
0
0%
0%
Preyer reflex
9
5
9
8
100%
100%
Jumping
0
0
0
0
0%
0%
Urination
1
Present
9
5
9
8
100%
100%
Absent
0
0
0
0
0%
0%
Touch Escape
1
No response
0
0
0
0
0%
0%
Response to touch
9
5
9
8
100%
100%
Flees prior to touch
0
0
0
0
0%
0%
Trunk Curl
1
Absent
9
5
9
8
100%
100%
Present
0
0
0
0
0%
0%
Table caption: Grip strength: Linear model for 4-paws grip strength (mean of 3 trials)
Table:
Estimate
CI
p-value
(Intercept)
195.53
[ 98.65 , 292.41 ]
<0.001
genotype1
2.45
[ -2.61 , 7.5 ]
0.33
sex1
-3.52
[ -11.61 , 4.57 ]
0.38
weight
-0.09
[ -4.37 , 4.2 ]
0.97
Table caption: Grip strength: Group means and standard deviation
Table:
female
male
con
mut
con
mut
n=9
n=5
n=9
n=8
mean ± sd
mean ± sd
mean ± sd
mean ± sd
Force 2 paws (mean)
95.89 ± 2.86
99.34 ± 2.98
96.86 ± 7.61
100.2 ± 7.18
Force 4 paws (mean)
194.13 ± 6.17
185.12 ± 10.57
197.99 ± 15.94
196.19 ± 16.69
Table caption: Grip strength: Linear model for 2-paws grip strength (mean of 3 trials)
Table:
Estimate
CI
p-value
(Intercept)
109.22
[ 67.05 , 151.4 ]
<0.001
genotype1
-1.76
[ -3.96 , 0.44 ]
0.11
sex1
-1.2
[ -4.72 , 2.33 ]
0.49
weight
-0.49
[ -2.36 , 1.37 ]
0.59
Table caption: ABR: Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test. Values above measurement limit (85db) are replaced by 100.$\^{a}$ Number not based on the full number of animals (missing values)
Table:
female
male
female
male
overall
con
mut
con
mut
n=4
n=4
n=4
n=4
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-value
p-value
p-value
Click ABR [dB]
35
[34 , 35]
30
[29 , 31]
30
[30 , 30]
28
[25 , 31]
0.371
0.429
0.297
Threshold at 6 kHz [dB]
58
[52 , 62]
45
[44 , 48]
48
[44 , 52]
60
[58 , 64]
0.2
0.2
0.97
Threshold at 12 kHz [dB]
32
[29 , 35]
30
[25 , 35]
32
[30 , 35]
35
[34 , 35]
1
1
1
Threshold at 18 kHz [dB]
30
[30 , 32]
28
[25 , 32]
32
[30 , 35]
38
[34 , 40]
0.629
0.4
0.956
Threshold at 24 kHz [dB]
38
[35 , 41]
35
[30 , 40]
35
[35 , 38]
40
[39 , 40]
0.514
0.486
0.841
Threshold at 30 kHz [dB]
58
[54 , 60]
55
[54 , 56]
52
[50 , 60]
50
[50 , 52]
0.914
0.714
0.605
Body weight ABR [g]
22.1
[21.6 , 22.4]
23.2
[23 , 23.8]
26.6
[26.1 , 27.7]
26.9
[26.4 , 27.6]
0.057
0.971
0.489
Media files
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