Selected project
Hmgn1
Graphics
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of female mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of male mice, boxplot, split by genotype
Graphic caption: Total IgE in Plasma: IgE boxplot with stripchart, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=10n=10n=10n=10   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 28.35 ± 2.7227.16 ± 522.78 ± 2.5220.77 ± 2.530.141< 0.0010.702
CD45+/CD3+CD4+ 13.31 ± 1.3912.65 ± 1.9211.1 ± 0.6510.09 ± 1.150.058< 0.0010.685
CD45+/CD3+CD8+ 11.46 ± 1.212.06 ± 1.728.87 ± 0.658.48 ± 0.970.778< 0.0010.197
CD45+/B cells 55.37 ± 2.5752.11 ± 3.764.45 ± 2.4865.05 ± 3.160.172< 0.0010.051
CD45+/CD5-NK+ 4 ± 0.583.95 ± 0.593.1 ± 0.492.9 ± 0.20.436< 0.0010.63
CD45+/CD11b+Gr1+ 6.59 ± 1.018.04 ± 1.976.77 ± 1.837.29 ± 1.840.0770.60.396
CD45+/NK-Gr1-CD11b+ 2.54 ± 1.062.11 ± 0.572.85 ± 1.492.39 ± 0.550.1650.3490.955
CD3+CD4+/CD25+ 4.72 ± 0.484.68 ± 0.555.88 ± 0.495.77 ± 0.450.63< 0.0010.829
CD45+/CD3+gammadeltaTCR+ 0.5 ± 0.060.51 ± 0.10.32 ± 0.040.34 ± 0.070.457< 0.0010.792
CD3+CD4+/CD62L+ 79.45 ± 1.5378.95 ± 1.6278.34 ± 1.8976.13 ± 4.880.1410.0350.348
CD3+CD4+/CD44+ 68.08 ± 2.8670.58 ± 3.0564.79 ± 2.8965.47 ± 3.430.11< 0.0010.354
CD3+CD8+/CD62L+ 90.06 ± 2.2990.5 ± 1.3188.6 ± 2.5186.2 ± 5.30.3420.0080.171
CD3+CD8+/CD44+ 56.73 ± 2.9656.67 ± 2.2257.58 ± 3.757.5 ± 2.740.9410.3740.992
CD45+/CD5+NK+ 0.43 ± 0.050.44 ± 0.10.32 ± 0.070.31 ± 0.050.911< 0.0010.546
B cells/IgD+ 93.27 ± 1.0792.76 ± 2.0892.96 ± 1.2592.49 ± 1.380.3060.5430.966
B cells/CD5+ 1.48 ± 0.231.58 ± 0.371.34 ± 0.261.15 ± 0.230.5940.0020.116
B cells/B220+MHCclassII+ 87.05 ± 1.3183.82 ± 9.8287.23 ± 1.387.62 ± 1.340.3790.220.264
NK+/CD11b+ 70.22 ± 2.5264.18 ± 13.3363.81 ± 5.3561.87 ± 4.020.1040.0770.397
CD3+ rest 3.58 ± 2.852.45 ± 2.642.8 ± 2.072.2 ± 2.10.2680.5070.734
CD45+/CD3+CD4+CD25+ 0.63 ± 0.070.59 ± 0.080.65 ± 0.060.58 ± 0.050.0110.6760.413
ratio CD4:CD8 1.17 ± 0.11.05 ± 0.071.25 ± 0.071.19 ± 0.10.002< 0.0010.327
ratio Granulocytes:(Tcells+B cells) 0.08 ± 0.010.1 ± 0.030.08 ± 0.020.09 ± 0.020.0410.2810.349
ratio Tcells:Bcells 0.51 ± 0.060.53 ± 0.130.36 ± 0.040.32 ± 0.060.69< 0.0010.341
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=10n=10n=10n=10   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 28.9
[26.62 , 30.18]
25.1
[24.9 , 28.3]
22.3
[21.23 , 24.35]
20.7
[19.55 , 21.38]
0.3050.0790.163
CD45+/CD3+CD4+ 13.1
[12.7 , 14.3]
12.3
[11.43 , 13.78]
11.05
[10.85 , 11.45]
10.25
[9.73 , 10.85]
0.4680.0240.103
CD45+/CD3+CD8+ 11.5
[10.5 , 12.05]
11.9
[11.25 , 13.15]
8.79
[8.49 , 9.25]
8.64
[7.89 , 8.96]
0.2710.5290.984
CD45+/B cells 55.75
[54.2 , 56.33]
52.6
[49.65 , 53.88]
63.4
[62.52 , 67.15]
65.3
[64.8 , 65.92]
0.030.5650.551
CD45+/CD5-NK+ 4
[3.71 , 4.27]
3.75
[3.54 , 4.15]
3.09
[2.85 , 3.31]
2.88
[2.76 , 3.01]
0.6690.1970.417
CD45+/CD11b+Gr1+ 6.54
[5.88 , 7.42]
7.59
[6.62 , 9.71]
6.86
[5.06 , 8.23]
6.7
[5.97 , 8.05]
0.0930.7960.122
CD45+/NK-Gr1-CD11b+ 2.29
[1.93 , 2.66]
2.08
[1.7 , 2.36]
2.39
[1.82 , 2.94]
2.19
[1.99 , 2.84]
0.43610.495
CD3+CD4+/CD25+ 4.78
[4.44 , 4.97]
4.66
[4.26 , 4.97]
5.79
[5.61 , 5.99]
5.72
[5.4 , 6]
0.8530.6310.799
CD45+/CD3+gammadeltaTCR+ 0.48
[0.47 , 0.52]
0.48
[0.46 , 0.56]
0.32
[0.3 , 0.35]
0.32
[0.31 , 0.36]
10.6140.804
CD3+CD4+/CD62L+ 79.2
[78.25 , 80.22]
79.55
[78.55 , 79.95]
78.15
[76.72 , 80.12]
77.4
[73.6 , 79.65]
0.7830.4940.449
CD3+CD4+/CD44+ 67.75
[66.9 , 68.67]
69.95
[68.12 , 72.78]
63.55
[62.73 , 66.1]
65.1
[62.52 , 67.83]
0.0650.7240.185
CD3+CD8+/CD62L+ 90.65
[88.25 , 91.8]
90.95
[90.05 , 91.38]
88.9
[87.62 , 90.38]
88.5
[82.2 , 89.5]
0.9270.3820.825
CD3+CD8+/CD44+ 55.85
[54.48 , 59.3]
56.8
[55.15 , 58.15]
57.1
[54.9 , 60.25]
57.2
[55.5 , 59.4]
0.9550.9540.909
CD45+/CD5+NK+ 0.44
[0.42 , 0.46]
0.4
[0.36 , 0.52]
0.3
[0.28 , 0.36]
0.3
[0.27 , 0.35]
0.9280.7240.663
B cells/IgD+ 93.7
[92.47 , 94]
92.35
[91.92 , 93.1]
93.2
[91.83 , 93.5]
91.9
[91.35 , 93.55]
0.1960.4470.115
B cells/CD5+ 1.48
[1.34 , 1.58]
1.43
[1.39 , 1.68]
1.29
[1.17 , 1.38]
1.15
[0.97 , 1.26]
0.9270.1090.49
B cells/B220+MHCclassII+ 87.3
[86.35 , 88]
86.45
[85.53 , 87.88]
87.75
[85.8 , 88.33]
87.3
[86.92 , 88.75]
0.5170.6970.941
NK+/CD11b+ 70.1
[68.8 , 70.8]
68.35
[65.72 , 69.9]
63.8
[61.2 , 65.8]
62.45
[59.88 , 65.25]
0.1370.4810.126
CD3+ rest 2.27
[1.12 , 6.38]
1.75
[1.07 , 2.3]
2.54
[0.95 , 4.04]
0.97
[0.7 , 3.15]
0.4680.280.155
CD45+/CD3+CD4+CD25+ 0.62
[0.61 , 0.67]
0.58
[0.55 , 0.63]
0.66
[0.62 , 0.68]
0.59
[0.53 , 0.62]
0.3150.0070.009
ratio CD4:CD8 1.16
[1.09 , 1.24]
1.05
[1.03 , 1.1]
1.24
[1.21 , 1.29]
1.16
[1.12 , 1.27]
0.0150.1370.011
ratio Granulocytes:(Tcells+B cells) 0.08
[0.07 , 0.09]
0.09
[0.08 , 0.12]
0.08
[0.06 , 0.1]
0.08
[0.07 , 0.09]
0.0620.5570.103
ratio Tcells:Bcells 0.52
[0.5 , 0.56]
0.47
[0.46 , 0.57]
0.34
[0.33 , 0.39]
0.32
[0.3 , 0.33]
0.6980.0550.394
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