Selected project
Fut1 / EPD0817_1_C05
Graphics
Graphic caption: Clinical Chemistry: Potassium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Albumin boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Total protein boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Urea boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Chloride boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Sodium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Creatinine enz. boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: ALAT/GPT boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: ASAT/GOT boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: Glucose boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: Triglyceride boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: Cholesterol boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: alpha-Amylase boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: Inorganic phosphate boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: Calcium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: ALP boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: Total bilirubin boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical chemistry: HDL-Cholesterol boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Red blood cell boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: White blood cell boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Hemoglobin boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Hematocrit boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Platelet boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular volume boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular hemoglobin content boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular hemoglobin concentration boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean platelets volume boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Distribution index of red blood cells boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: Body mass loss vs. body weight before food withdrawal
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Graphic caption: IpGTT: Blood glucose concentration average plot, split by genotype and sex
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Graphic caption: IpGTT: Glucose (T=0) boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: AUC 0-30 boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: AUC 30-120 boxplot with stripchart, split by sex and genotype
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Tables
Table caption: Clinical Chemistry: Means, Standard deviations and p-values of a Wilcoxon test.
Table:
female
male
female
male
overall
con
mut
con
mut
n=18
n=10
n=19
n=10
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-value
p-value
p-value
Sodium [mmol/l]
152
[150 , 156]
152
[150 , 152]
155
[154 , 156]
155
[153 , 155]
0.237
0.185
0.078
Potassium [mmol/l]
3.9
[3.8 , 4.2]
3.9
[3.8 , 4]
4.5
[4.3 , 4.6]
4.8
[4.4 , 5]
0.663
0.083
0.712
Chloride [mmol/l]
113.6
[112 , 114.8]
112.4
[112 , 113.1]
111.9
[111.5 , 113.2]
112.3
[110.5 , 113.4]
0.457
0.778
0.593
Total protein [g/l]
48.9
[48.5 , 50.1]
49.6
[48.7 , 51.1]
50.4
[49.9 , 50.9]
49
[47.5 , 50.1]
0.401
0.067
0.409
Albumin [g/l]
27.7
[27.4 , 28.3]
28.2
[27.2 , 28.5]
27.3
[27 , 27.6]
26.2
[25.4 , 27.2]
0.579
0.023
0.288
Creatinine enz. [µmol/l]
8.62
[7.76 , 9.55]
7.96
[7.36 , 9.46]
7.51
[6.81 , 8.39]
8.48
[7 , 10.37]
0.68
0.261
0.553
Urea [mmol/l]
11.12
[10.29 , 11.8]
10.69
[9.8 , 12.02]
11.17
[10.44 , 11.96]
11.79
[10.39 , 12.82]
0.697
0.58
0.977
Table caption: Clinical chemistry: Lipid and glucose levels as well as selected enzyme activities in plasma of ad libitum fed mice. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
linear model
linear model
linear model
con
mut
con
mut
genotype
sex
genotype:sex
n=18
n=10
n=19
n=10
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Cholesterol [mmol/l]
2.12 ± 0.263
2.254 ± 0.3
2.509 ± 0.385
2.498 ± 0.446
0.527
0.002
0.454
Triglyceride [mmol/l]
1.134 ± 0.406
1.231 ± 0.289
1.819 ± 0.534
1.938 ± 0.706
0.439
< 0.001
0.938
ALAT/GPT [U/l]
39 ± 27
29 ± 13
45 ± 27
33 ± 22
0.128
0.463
0.887
ASAT/GOT [U/l]
58 ± 21
50 ± 9
51 ± 8
46 ± 7
0.096
0.155
0.72
alpha-Amylase [U/l]
535.34 ± 52.31
567.24 ± 82.11
679.83 ± 102.88
631.61 ± 68.69
0.715
< 0.001
0.077
Glucose [mmol/l]
16.17 ± 1.91
15.83 ± 2.59
14.98 ± 2.02
14.07 ± 2.01
0.285
0.014
0.627
Table caption: Hematology: Values measured in EDTA-blood samples. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
linear model
linear model
linear model
con
mut
con
mut
genotype
sex
genotype:sex
n=18
n=10
n=19
n=10
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
RBC [Mio/mm³]
10.65 ± 0.79
11.14 ± 1.62
11.2 ± 0.64
10.65 ± 0.74
0.913
0.916
0.053
HGB [g/dl]
16.42 ± 1.16
17.19 ± 2.58
16.88 ± 0.85
16.25 ± 1.25
0.868
0.552
0.085
HCT [%]
51.36 ± 3.44
53.44 ± 7.3
53.48 ± 2.51
51.3 ± 3.49
0.965
0.992
0.069
MCV [fl]
48.39 ± 0.85
48.1 ± 0.99
47.79 ± 0.92
48.3 ± 0.82
0.657
0.425
0.113
MCH [pg]
15.41 ± 0.45
15.44 ± 0.39
15.09 ± 0.45
15.27 ± 0.36
0.378
0.042
0.523
MCHC [g/dl]
31.98 ± 0.67
32.13 ± 0.65
31.58 ± 0.76
31.67 ± 0.51
0.528
0.027
0.86
RDW [%]
13.67 ± 0.39
13.76 ± 0.25
14.2 ± 0.69
14.95 ± 1.07
0.023
< 0.001
0.07
WBC [10³/mm³]
7.25 ± 1.9
7.4 ± 2.37
10.08 ± 1.89
8.24 ± 2.08
0.137
0.002
0.081
PLT [10³/mm³]
849.06 ± 140.93
975.7 ± 229.13
1064.05 ± 146.64
1094.2 ± 220.32
0.114
0.001
0.327
MPV [fl]
6.27 ± 0.12
6.35 ± 0.11
6.09 ± 0.11
6.17 ± 0.15
0.026
< 0.001
0.97
PDW [fL]
5.55 ± 0.22
5.6 ± 0.14
5.28 ± 0.15
5.38 ± 0.19
0.149
< 0.001
0.648
PLCR [%]
2.32 ± 0.59
2.66 ± 0.49
1.96 ± 0.51
2.11 ± 0.53
0.108
0.004
0.515
PCT [%]
0.53 ± 0.09
0.62 ± 0.16
0.65 ± 0.09
0.67 ± 0.13
0.074
0.009
0.303
Table caption: IpGTT: Basal glucose level and area under the curve (AUC) for the first 30 minutes and the remaining 90 minutes of the test obtained from glucose tolerance testing: Means, standard deviation and p-values calculated by a linear model.
Table:
female
male
linear model
linear model
linear model
con
mut
con
mut
genotype
sex
genotype:sex
n=19
n=10
n=20
n=10
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Glucose (T=0)
5.53 ± 0.72
5.83 ± 0.44
5.75 ± 0.89
5.9 ± 0.88
0.307
0.498
0.734
AUC 0-30
326.53 ± 81.97
348.24 ± 60.05
a
367.87 ± 74.42
383.42 ± 69.91
0.375
0.072
0.883
AUC 30-120
415.74 ± 120.32
484.87 ± 123.89
a
768.09 ± 210.42
759.48 ± 208.85
0.535
< 0.001
0.426
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