Selected project
Wsb2 / HEPD0508_2_A11-tm1b
Graphics
Graphic caption: SHIRPA: Locomotor Activity boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Grip Strength: bodyweight boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Grip Strength: Mean force (2 and 4 paws) boxplot, split by sex and genotype
Graphic:
Graphic caption: Grip Strength: Mean force (2 and 4 paws) scatterplot, split by sex and genotype
Graphic:
Graphic caption: Rotarod: Latency to fall (mean) boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Rotarod: Latency to fall (mean) vs. weight scatterplot with regression lines
Graphic:
Graphic caption: Rotarod: Latency to fall, average plot, split by sex and genotype
Graphic:
Graphic caption: Rotarod: Passive rotation proportion bar plot, split by sex and genotype
Graphic:
Tables
Table caption: SHIRPA: Locomotor activity and body mass (SHIRPA): Means, standard deviation and p-values calculated by a linear model
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=8
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Weight
19.56 ± 1.16
15.84 ± 1.13
24.41 ± 1.28
20.93 ± 1.87
< 0.001
< 0.001
0.822
Locomotor Activity
19.12 ± 6.88
26 ± 6.63
20.14 ± 5.76
25.86 ± 9.69
0.03
0.874
0.834
Table caption: SHIRPA: Results ($^{1}$ Fisher's Exact test)
Table:
Female
Male
Both
Control
Mutant
Control
Mutant
Control
Mutant
p value
1
n=8
n=7
n=7
n=7
51.7%
48.3%
Absolute
Absolute
Percent
Limb Grasping
1
Absent
8
7
7
7
100%
100%
Present
0
0
0
0
0%
0%
Pinna Reflex
1
Present
0
0
0
0
NaN%
NaN%
Absent
0
0
0
0
NaN%
NaN%
Contact Righting Reflex
1
Present
8
7
7
7
100%
100%
Absent
0
0
0
0
0%
0%
Evidence Of Biting
1
No aggression
8
7
7
7
100%
100%
Aggressive
0
0
0
0
0%
0%
Vocalisation
0.48276
No
8
7
5
7
86.7%
100%
Yes
0
0
2
0
13.3%
0%
Unexpected Behaviors
1
None
8
7
7
7
100%
100%
Circling
0
0
0
0
0%
0%
Jumping
0
0
0
0
0%
0%
Retropulsion
0
0
0
0
0%
0%
Other
0
0
0
0
0%
0%
Head Bobbing
1
Absent
8
7
7
7
100%
100%
Present
0
0
0
0
0%
0%
Table caption: SHIRPA: Results ($^{1}$ Fisher's Exact test)
Table:
Female
Male
Both
Control
Mutant
Control
Mutant
Control
Mutant
p value
1
n=8
n=7
n=7
n=7
51.7%
48.3%
Absolute
Absolute
Percent
Body Position
1
Inactive
0
0
0
0
0%
0%
Active
8
7
7
7
100%
100%
Excessively Active
0
0
0
0
0%
0%
Tremor
1
Absent
8
7
7
7
100%
100%
Present
0
0
0
0
0%
0%
Defecation
1
Present
0
0
0
0
NaN%
NaN%
Absent
0
0
0
0
NaN%
NaN%
Transfer Arousal
1
Prolongued freeze
0
1
0
0
0%
7.1%
Brief freeze
2
1
3
3
33.3%
28.6%
Immediate movement
6
5
4
4
66.7%
64.3%
Gait
1
Fluid
8
7
7
7
100%
100%
Abnormal
0
0
0
0
0%
0%
Tail Elevation
< 0.00001
Dragging
0
0
0
0
0%
0%
Horizontal
8
1
7
0
100%
7.1%
Elevated
0
6
0
7
0%
92.9%
Startle Response
1
No reaction
0
0
0
0
0%
0%
Preyer reflex
8
7
7
7
100%
100%
Jumping
0
0
0
0
0%
0%
Urination
1
Present
0
0
0
0
NaN%
NaN%
Absent
0
0
0
0
NaN%
NaN%
Touch Escape
1
No response
0
0
0
0
0%
0%
Response to touch
8
7
7
7
100%
100%
Flees prior to touch
0
0
0
0
0%
0%
Trunk Curl
1
Absent
8
7
7
7
100%
100%
Present
0
0
0
0
0%
0%
Table caption: Grip Strength: Linear model for 4-paws grip strength (mean of 3 trials)
Table:
Estimate
CI
p-value
(Intercept)
228.71
[ 1 , 456.41 ]
0.05
genotype1
8.52
[ -16.43 , 33.46 ]
0.49
sex1
-14.14
[ -45.62 , 17.34 ]
0.36
weight
-1.89
[ -13.14 , 9.37 ]
0.73
Table caption: Grip Strength: AIC-optimal linear model for 4-paws grip strength (mean of 3 trials)
Table:
Estimate
CI
p-value
(Intercept)
171.46
[ -50.76 , 393.68 ]
0.12
genotype1
-272.34
[ -494.56 , -50.12 ]
0.02
sex1
-85.81
[ -308.03 , 136.41 ]
0.43
weight
0.01
[ -11.07 , 11.09 ]
1
genotype1:sex1
-117.85
[ -340.07 , 104.37 ]
0.28
genotype1:weight
14.63
[ 3.55 , 25.71 ]
0.01
sex1:weight
3.1
[ -7.98 , 14.18 ]
0.57
genotype1:sex1:weight
7.21
[ -3.87 , 18.29 ]
0.19
Table caption: Grip Strength: Group means and standard deviation
Table:
female
male
control
mutant
control
mutant
n=8
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
mean force (2 paws)
90.38 ± 15.99
93.94 ± 15.5
94.2 ± 7.88
100.67 ± 12.87
mean force (4 paws)
183.47 ± 35.78
179.16 ± 33.93
208.27 ± 28.8
191.76 ± 49.88
Table caption: Grip Strength: Linear model for 2-paws grip strength (mean of 3 trials)
Table:
Estimate
CI
p-value
(Intercept)
41.35
[ -37.25 , 119.96 ]
0.29
genotype1
-7.26
[ -15.87 , 1.35 ]
0.09
sex1
3.96
[ -6.91 , 14.83 ]
0.46
weight
2.65
[ -1.24 , 6.53 ]
0.17
Table caption: Grip Strength: AIC-optimal linear model for 2-paws grip strength (mean of 3 trials)
Table:
Estimate
CI
p-value
(Intercept)
35.83
[ -44.23 , 115.89 ]
0.36
genotype1
-83.07
[ -163.13 , -3.02 ]
0.04
sex1
-9.13
[ -89.18 , 70.93 ]
0.81
weight
2.57
[ -1.42 , 6.57 ]
0.19
genotype1:sex1
-61.37
[ -141.42 , 18.69 ]
0.13
genotype1:weight
4.2
[ 0.21 , 8.19 ]
0.04
sex1:weight
0.31
[ -3.68 , 4.3 ]
0.87
genotype1:sex1:weight
3.56
[ -0.43 , 7.55 ]
0.08
Table caption: Rotarod: Linear Mixed Effect Model
Table:
Estimate
p-value
(Intercept)
264.202
0.061
sexm
51.778
0.134
genotypemutant
-32.328
0.347
measurement2
35.174
0.009
measurement3
63.522
<0.001
bw_rod
-10.705
0.122
Table caption: Rotarod: Passive Rotation \$^{1}$ Fisher's Exact test ($alpha=$0.05)
Table:
Male
Female
Both
Control
Mutant
Control
Mutant
Control
Mutant
Control
Mutant
p value
1
n=12
n=12
n=24
n=21
n=36
n=33
41.4%
37.9%
Absolute
Absolute
Absolute
Absolute
Absolute
Absolute
Percent
Percent
Passive rotation
0.07178
f
11
9
21
14
32
23
88.9%
69.7%
p
1
3
3
7
4
10
11.1%
30.3%
j
0
0
0
0
0
0
0%
0%
Media files
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