Selected project
Wsb2 / HEPD0508_2_A11-tm1b
Graphics
Graphic caption: Clinical Chemistry: Potassium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Albumin boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Total protein boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Urea boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Chloride boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Sodium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Creatinine enz. boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: ALAT/GPT boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: ASAT/GOT boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Glucose boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Triglyceride boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Cholesterol boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: alpha-Amylase boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Inorganic phosphate boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Calcium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: ALP boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Total bilirubin boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: HDL-Cholesterol boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Red blood cell boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: White blood cell boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Hemoglobin boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Hematocrit boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Platelet boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular volume boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular hemoglobin content boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular hemoglobin concentration boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean platelets volume boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Distribution index of red blood cells boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: Body mass loss vs. body weight before overnight food withdrawal
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Graphic caption: IpGTT: Blood glucose concentration average plot, split by sex and genotype
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Graphic caption: IpGTT: Glucose (T=0) boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: AUC 0-30 boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: AUC 30-120 boxplot with stripchart, split by sex and genotype
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Graphic caption: Insulin Blood Level: Plasma insulin concentration boxplot with stripchart, split by sex and genotype
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Tables
Table caption: Clinical Chemistry: Means, Standard deviations and p-values of a Wilcoxon test.$\^{a}$ Number not based on the full number of animals (missing values)
Table:
female
male
female
male
overall
control
mutant
control
mutant
n=7
n=6
n=7
n=5
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-value
p-value
p-value
Sodium [mmol/l]
148
[147 , 149]
148
[147 , 149]
148
[147 , 149]
147
[145 , 147]
1
0.207
0.406
Potassium [mmol/l]
4.3
[4.2 , 4.7]
5
[4.8 , 5.1]
4.2
[4.2 , 4.5]
4.8
[4.3 , 4.9]
0.024
0.278
0.012
Chloride [mmol/l]
112.4
[111.6 , 112.7]
113.1
[111.6 , 114.1]
110.1
[110 , 110.3]
111.2
[111.1 , 111.7]
0.366
0.077
0.13
Total protein [g/l]
47.5
a
[47.2 , 47.7]
45.9
a
[43.5 , 47.9]
47.5
a
[47 , 47.8]
48.4
a
[47.5 , 48.5]
0.73
0.629
0.977
Albumin [g/l]
33.1
[29.8 , 33.5]
31.4
[29.7 , 33.5]
30.2
[26.9 , 31.2]
31.6
[31.1 , 32.1]
0.836
0.202
0.324
Creatinine enz. [mumol/l]
28.73
[19.27 , 31.2]
29.35
a
[28.91 , 30.32]
27.76
[8.53 , 28.86]
26.08
[9.28 , 26.7]
0.755
0.668
0.989
Urea [mmol/l]
12.09
[10.95 , 13.36]
12.88
[11.16 , 13.86]
11.85
[11.12 , 11.93]
12.04
[11.82 , 14.25]
0.366
0.343
0.166
Table caption: Clinical Chemistry: Plasma concentrations of minerals, iron and ALP activity of ad libitum fed mice. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=7
n=6
n=7
n=5
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Calcium [mmol/l]
2.47 ± 0.06
2.48 ± 0.1
2.45 ± 0.04
2.43 ± 0.09
0.979
0.269
0.496
Inorganic phosphate [mmol/l]
2.7 ± 0.5
2.7 ± 1.3
2.3 ± 0.4
1.5 ± 0.4
0.199
0.012
0.156
Iron [mumol/l]
24.4 ± 4
29.5 ± 2.1
21.6 ± 1.6
22.8 ± 1.9
0.008
< 0.001
0.088
ALP [U/l]
130 ± 14
201 ± 36
93 ± 11
123 ± 9
< 0.001
< 0.001
0.024
Table caption: Hematology: Values measured in EDTA-blood samples. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=8
n=6
n=7
n=5
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
RBC [Mio/mm³]
10.25 ± 0.54
10.93 ± 0.77
11.38 ± 0.36
11.54 ± 0.9
0.114
0.002
0.323
HGB [g/dl]
15.72 ± 0.76
16.9 ± 1.18
17.17 ± 0.93
17.58 ± 1.29
0.064
0.016
0.355
HCT [percent]
49.54 ± 2.24
54.05 ± 3.06
54.1 ± 1.65
55.42 ± 3.88
0.012
0.011
0.15
MCV [fl]
48.25 ± 1.16
49.5 ± 1.52
47.43 ± 0.53
48.2 ± 0.84
0.028
0.022
0.583
MCH [pg]
15.35 ± 0.6
15.45 ± 0.58
15.09 ± 0.4
15.24 ± 0.5
0.554
0.275
0.899
MCHC [g/dl]
31.75 ± 0.88
31.27 ± 0.85
31.7 ± 0.87
31.72 ± 0.68
0.494
0.551
0.458
RDW [percent]
14.01 ± 0.25
13.38 ± 0.41
13.77 ± 0.42
13.32 ± 0.49
0.002
0.334
0.57
WBC [10³/mm³]
3.16 ± 1.25
4.65 ± 1.61
6.3 ± 1.77
8.76 ± 4.34
0.044
0.001
0.603
PLT [10³/mm³]
997.25 ± 107.71
1064.33 ± 52.55
1127.71 ± 203.95
1219 ± 84.28
0.141
0.012
0.818
MPV [fl]
6.11 ± 0.11
6.08 ± 0.17
6.03 ± 0.18
6 ± 0.1
0.625
0.165
0.996
PDW [fL]
5.33 ± 0.23
5.28 ± 0.23
5.29 ± 0.26
5.24 ± 0.15
0.635
0.654
0.982
PLCR [percent]
1.96 ± 0.38
1.83 ± 0.46
1.86 ± 0.45
1.56 ± 0.27
0.201
0.254
0.608
PCT [percent]
0.61 ± 0.06
0.65 ± 0.03
0.68 ± 0.11
0.73 ± 0.05
0.1
0.008
0.75
Table caption: IpGTT: Linear model including sex, genotype and body mass before overnight food withdrawal as well as sex:genotype interaction as factors influencing fasting-induced body mass loss.
Table:
Estimate
CI
p-value
(Intercept)
2.26
[ -0.35 , 4.86 ]
0.09
genotypemutant
-0.27
[ -0.99 , 0.45 ]
0.44
sexm
-0.15
[ -0.92 , 0.61 ]
0.68
bw_before
0.02
[ -0.1 , 0.14 ]
0.68
genotypemutant:sexm
0.11
[ -0.73 , 0.94 ]
0.8
Table caption: IpGTT: Basal glucose level and area under the curve (AUC) for the first 30 minutes and the remaining 90 minutes of the test obtained from glucose tolerance testing: Means, standard deviation and p-values calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=8
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Glucose (T=0)
4.91 ± 0.81
3.87 ± 0.31
a
5.68 ± 1.09
5.53 ± 0.86
0.131
0.004
0.254
AUC 0-30
246.59 ± 46.75
324.88 ± 88.21
a
332.94 ± 75.18
317.22 ± 64.17
0.279
0.177
0.11
AUC 30-120
384.71 ± 44.79
600.25 ± 189.44
a
660.19 ± 122.73
662.87 ± 203.39
0.09
0.012
0.097
Media files
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