Selected project
Mocs2 / EPD0560_5_C09-tm1b
Graphics
Graphic caption: Clinical Chemistry: Potassium boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Clinical Chemistry: Albumin boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Total protein boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Clinical Chemistry: Urea boxplot with stripchart, split by sex and genotype
Graphic:
Graphic caption: Clinical Chemistry: Chloride boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Sodium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Creatinine enz. boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: ALAT/GPT boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: ASAT/GOT boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Glucose boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Triglyceride boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Cholesterol boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: alpha-Amylase boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Inorganic phosphate boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Calcium boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: ALP boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: Total bilirubin boxplot with stripchart, split by sex and genotype
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Graphic caption: Clinical Chemistry: HDL-Cholesterol boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Red blood cell boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: White blood cell boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Hemoglobin boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Hematocrit boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Platelet boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular volume boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular hemoglobin content boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean corpuscular hemoglobin concentration boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Mean platelets volume boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Distribution index of red blood cells boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Calculated Distribution width of platelets boxplot with stripchart, split by sex and genotype
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Graphic caption: Hematology: Platelet Large Cell ratio boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: Body mass loss vs. body weight before overnight food withdrawal
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Graphic caption: IpGTT: Blood glucose concentration average plot, split by sex and genotype
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Graphic caption: IpGTT: Glucose (T=0) boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: AUC 0-30 boxplot with stripchart, split by sex and genotype
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Graphic caption: IpGTT: AUC 30-120 boxplot with stripchart, split by sex and genotype
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Graphic caption: Insulin Blood Level: Plasma insulin concentration boxplot with stripchart, split by sex and genotype
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Tables
Table caption: Clinical Chemistry: Means, Standard deviations and p-values of a Wilcoxon test.$\^{a}$ Number not based on the full number of animals (missing values)
Table:
female
male
female
male
overall
control
mutant
control
mutant
n=7
n=7
n=7
n=7
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-value
p-value
p-value
Sodium [mmol/l]
147
[146 , 148]
146
[144 , 146]
149
[148 , 149]
146
[144 , 146]
0.11
0.002
0.001
Potassium [mmol/l]
4.3
[4.2 , 4.9]
4
[4 , 4.2]
4.4
[4 , 4.7]
4.6
[4.4 , 4.8]
0.041
0.433
0.432
Chloride [mmol/l]
110.5
[110.3 , 111.9]
111.2
[110.3 , 111.3]
110.1
[109.1 , 110.4]
109.1
[108.2 , 109.8]
0.825
0.304
0.518
Total protein [g/l]
48.3
[47.1 , 49.4]
48.8
[47 , 49.7]
50.1
[49 , 50.8]
51
[49.6 , 51.8]
0.973
0.334
0.504
Albumin [g/l]
26.9
[26 , 27.6]
27.7
[26.8 , 28.1]
26.9
[26.4 , 27.7]
27.6
[27.2 , 28.2]
0.477
0.197
0.117
Creatinine enz. [mumol/l]
12.55
[9.54 , 14.76]
8.66
[8.27 , 10.12]
9.64
[8.04 , 10.96]
8.22
[7.03 , 9.28]
0.038
0.245
0.032
Urea [mmol/l]
10.89
[9.9 , 11.58]
10.69
[9.84 , 12.49]
11.56
[11.09 , 12.09]
12.15
[10.07 , 12.3]
0.682
1
0.83
Table caption: Clinical Chemistry: Lipid and glucose levels as well as selected enzyme activities in plasma of ad libitum fed mice. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=7
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Cholesterol [mmol/l]
1.952 ± 0.157
1.756 ± 0.352
2.205 ± 0.225
2.208 ± 0.338
0.369
0.003
0.354
Triglyceride [mmol/l]
0.702 ± 0.194
0.881 ± 0.267
1.63 ± 0.235
1.468 ± 0.323
0.934
< 0.001
0.095
ALAT/GPT [U/l]
50 ± 27
30 ± 4
36 ± 12
46 ± 14
0.419
0.928
0.025
ASAT/GOT [U/l]
55 ± 13
53 ± 11
56 ± 23
52 ± 6
0.617
0.99
0.887
alpha-Amylase [U/l]
580.02 ± 52.93
564.09 ± 30.93
691.27 ± 73.62
718.07 ± 84.1
0.823
< 0.001
0.384
Glucose [mmol/l]
16.31 ± 1.49
16.27 ± 2.17
16.72 ± 1.97
16.17 ± 2.47
0.708
0.844
0.746
Table caption: Clinical Chemistry: Plasma concentrations of minerals, iron and ALP activity of ad libitum fed mice. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=7
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Calcium [mmol/l]
2.48 ± 0.04
2.41 ± 0.04
2.48 ± 0.04
2.41 ± 0.05
0.001
0.965
0.895
Inorganic phosphate [mmol/l]
2.8 ± 0.7
2.5 ± 0.6
2.4 ± 0.8
a
1.5 ± 0.5
0.048
0.014
0.329
Iron [mumol/l]
23.1 ± 4.1
26.4 ± 5.9
21.8 ± 2.5
18.7 ± 1.4
0.981
0.005
0.037
ALP [U/l]
143 ± 21
150 ± 19
90 ± 9
105 ± 8
0.074
< 0.001
0.518
Table caption: Hematology: Values measured in EDTA-blood samples. Means, standard deviations and p-values for genotype, sex and genotype $ imes$ sex interaction effects calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=7
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
RBC [Mio/mm³]
10.79 ± 0.63
10.63 ± 0.3
11.26 ± 0.68
11.63 ± 0.58
0.641
0.002
0.224
HGB [g/dl]
16.59 ± 1.07
16.56 ± 0.71
17.06 ± 0.88
17.53 ± 0.72
0.501
0.036
0.448
HCT [percent]
53.33 ± 2.97
53.2 ± 1.22
55.19 ± 2.92
57.3 ± 2.05
0.285
0.003
0.229
MCV [fl]
49.43 ± 1.27
50 ± 0.82
49.14 ± 0.9
49.29 ± 1.11
0.373
0.216
0.591
MCH [pg]
15.36 ± 0.44
15.57 ± 0.49
15.13 ± 0.35
15.07 ± 0.35
0.617
0.027
0.39
MCHC [g/dl]
31.09 ± 0.79
31.11 ± 0.81
30.9 ± 0.67
30.6 ± 0.31
0.6
0.183
0.526
RDW [percent]
15.24 ± 0.56
15.21 ± 0.46
15.46 ± 0.29
15.16 ± 0.28
0.301
0.618
0.391
WBC [10³/mm³]
4.69 ± 2.05
4.21 ± 0.9
7.77 ± 1.91
8 ± 1.72
0.852
< 0.001
0.592
PLT [10³/mm³]
856 ± 76.35
793.14 ± 144.25
1080.57 ± 195.41
971.14 ± 144.17
0.132
0.001
0.677
MPV [fl]
6.14 ± 0.1
6.11 ± 0.09
6.01 ± 0.07
5.93 ± 0.08
0.084
< 0.001
0.376
PDW [fL]
5.37 ± 0.15
5.23 ± 0.11
5.06 ± 0.11
5.13 ± 0.1
0.435
< 0.001
0.026
PLCR [percent]
2.11 ± 0.42
2.1 ± 0.37
2.04 ± 0.3
1.61 ± 0.29
0.109
0.047
0.133
PCT [percent]
0.53 ± 0.04
0.49 ± 0.09
0.65 ± 0.12
0.58 ± 0.08
0.099
0.004
0.612
Table caption: IpGTT: Linear model including sex, genotype and body mass before overnight food withdrawal as well as sex:genotype interaction as factors influencing fasting-induced body mass loss.
Table:
Estimate
CI
p-value
(Intercept)
0.92
[ -1.5 , 3.34 ]
0.44
genotypemutant
-0.02
[ -0.54 , 0.51 ]
0.95
sexm
-0.65
[ -1.3 , 0 ]
0.05
bw_before
0.1
[ -0.02 , 0.21 ]
0.09
genotypemutant:sexm
0.2
[ -0.52 , 0.91 ]
0.58
Table caption: IpGTT: Basal glucose level and area under the curve (AUC) for the first 30 minutes and the remaining 90 minutes of the test obtained from glucose tolerance testing: Means, standard deviation and p-values calculated by a linear model.
Table:
female
male
Linear model
Linear model
Linear model
control
mutant
control
mutant
genotype
sex
genotype:sex
n=7
n=7
n=7
n=7
mean ± sd
mean ± sd
mean ± sd
mean ± sd
p-value
p-value
p-value
Glucose (T=0)
6.41 ± 0.51
7.1 ± 1.72
6.42 ± 0.52
7.51 ± 1.95
0.097
0.685
0.698
AUC 0-30
281.54 ± 42.06
265.99 ± 48.86
331.08 ± 46.4
355.04 ± 43.71
0.808
< 0.001
0.26
AUC 30-120
292.44 ± 63.33
314.42 ± 145.98
579.04 ± 150.57
699.47 ± 207.43
0.224
< 0.001
0.397
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