Selected project
Rosa26 Aox
Graphics
Graphic caption: B cell subsets: B-2 B cell subpopulations pie chart, split by sex and genotype
Graphic caption: B cell subsets: B/CD11b+ boxplot with stripchart, split by sex and genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of female mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of male mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Rheumatoid factor strip chart with means, split by sex and genotype
Graphic caption: Immunglobulins: anti DNA antibodies strip chart with means, split by sex and genotype
Graphic caption: Main leukocyte populations: CD45+/NKTcells boxplot with stripchart, split by sex and genotype
Graphic caption: Main leukocyte populations: CD45+/NKcells boxplot with stripchart, split by sex and genotype
Graphic caption: Main leukocyte populations: Frequencies of main leukocyte populations of female mice, boxplot, split by genotype
Graphic caption: Main leukocyte populations: Frequencies of main leukocyte populations of male mice, boxplot, split by genotype
Graphic caption: Main leukocyte populations: Leukocytes pie chart, split by sex and genotype
Graphic caption: Monocyte subsets: Monocyte pie chart, split by sex and genotype
Graphic caption: Monocyte subsets: monocytes/Ly6C-CD11c+ boxplot with stripchart, split by sex and genotype
Graphic caption: NK cell subsets: NK/CD11b+ boxplot with stripchart, split by sex and genotype
Graphic caption: NK cell subsets: NK/CD11c+ boxplot with stripchart, split by sex and genotype
Graphic caption: T cell subsets: CD4 T cell subpopulations pie chart, split by sex and genotype
Graphic caption: T cell subsets: CD8 T cell subpopulations pie chart, split by sex and genotype
Graphic caption: T cell subsets: T cell subpopulations pie chart, split by sex and genotype
Tables
Table caption: B cell subsets: B-2 B cell subpopulations (Boolean gates CD21,CD23, IgD, IgM). Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=15n=15n=15n=15   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
B2/CD21+CD23+IgD+IgM+ 24.5
[9.73 , 63.15]
10.4
[8.54 , 27.7]
29.1
[18.05 , 53.8]
28.7
[12.4 , 49]
0.3050.3450.134
B2/CD21+CD23+IgD+IgM- 56
[16.26 , 73.6]
70.2
[56.05 , 74]
54.8
[33.35 , 64.9]
58.8
[36.2 , 73.9]
0.2370.4540.143
B2/CD21+CD23+IgD-IgM+ 0.4
[0.32 , 0.88]
0.34
[0.2 , 0.66]
0.56
[0.48 , 1.03]
0.51
[0.36 , 0.86]
0.3290.5460.315
B2/CD21+CD23+IgD-IgM- 1.39
[1.24 , 2.1]
1.34
[1.09 , 1.54]
1.32
[1.05 , 1.71]
1.31
[1.01 , 1.58]
0.5060.7360.417
B2/CD21+CD23-IgD+IgM+ 2.23
[1.3 , 2.48]
1.59
[0.88 , 2.25]
1.82
[1.47 , 2.46]
1.81
[1.09 , 2.25]
0.3510.560.243
B2/CD21+CD23-IgD+IgM- 1.64
[0.51 , 1.81]
1.44
[0.98 , 2.12]
1.02
[0.72 , 1.42]
1.16
[0.46 , 1.56]
0.7210.7830.772
B2/CD21+CD23-IgD-IgM+ 0.57
[0.29 , 0.67]
0.49
[0.33 , 0.74]
0.7
[0.48 , 0.91]
0.53
[0.41 , 0.73]
0.7670.4180.511
B2/CD21+CD23-IgD-IgM- 0.68
[0.55 , 1.17]
0.57
[0.55 , 0.78]
0.51
[0.36 , 0.78]
0.57
[0.43 , 0.85]
0.4670.6450.892
B2/CD21-CD23+IgD+IgM+ 0.54
[0.28 , 1.43]
0.48
[0.4 , 0.62]
0.78
[0.48 , 0.88]
0.56
[0.32 , 0.79]
0.9270.2540.33
B2/CD21-CD23+IgD+IgM- 1.81
[0.49 , 2.7]
3.02
[1.5 , 3.42]
1.19
[0.72 , 1.64]
1.59
[0.44 , 2.29]
0.3250.5320.147
B2/CD21-CD23+IgD-IgM+ 0.28
[0.17 , 0.42]
0.26
[0.18 , 0.33]
0.32
[0.25 , 0.62]
0.31
[0.19 , 0.57]
0.8460.5320.579
B2/CD21-CD23+IgD-IgM- 1.52
[1.27 , 2.24]
1.41
[1.21 , 1.57]
1.08
[0.96 , 1.5]
1.27
[0.88 , 1.5]
0.4670.7510.755
B2/CD21-CD23-IgD+IgM+ 0.29
[0.23 , 0.75]
0.48
[0.3 , 0.78]
0.65
[0.52 , 0.88]
0.57
[0.32 , 0.71]
0.3610.330.875
B2/CD21-CD23-IgD+IgM- 0.78
[0.28 , 1.11]
0.83
[0.57 , 1.02]
0.44
[0.36 , 0.58]
0.6
[0.2 , 0.76]
0.7830.7980.569
B2/CD21-CD23-IgD-IgM+ 0.88
[0.5 , 1.46]
1.06
[0.58 , 1.91]
1.21
[0.9 , 1.74]
0.9
[0.61 , 1.57]
0.2540.2810.944
B2/CD21-CD23-IgD-IgM- 3.19
[1.92 , 4.21]
3.15
[2.43 , 3.46]
2.08
[1.68 , 2.8]
2.06
[1.77 , 2.59]
0.8380.9910.857
Table caption: B cell subsets: Summary of total leukocyte count and B cells count
Table caption: T cell subsets: Frequencies of CD4 and CD8 T cell subpopulations (Boolean gates CD44 high, CD62L, Ly6C). Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=15n=15n=15n=15   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
4+/44++62L+6C+ 3.35
[2.48 , 4.86]
2.94
[2.33 , 3.42]
3.41
[3.04 , 3.85]
3.2
[2.75 , 3.62]
0.2540.690.193
4+/44++62L+6C- 0.41
[0.12 , 1.18]
1.48
[0.25 , 2.04]
0.46
[0.24 , 1.19]
0.71
[0.12 , 1.42]
0.1160.9920.249
4+/44++62L-6C+ 8.64
[5.09 , 9.75]
4.81
[3.56 , 8.03]
6.11
[4.94 , 7.26]
4.64
[3.62 , 7.29]
0.0370.5670.048
4+/44++62L-6C- 4.89
[0.68 , 7.36]
6.44
[2.5 , 8.18]
3.09
[2.15 , 4.36]
3.8
[1.74 , 6.08]
0.3050.3450.158
4+/44-62L+6C+ 77.2
[64.45 , 81.05]
75.7
[63.05 , 78.8]
78.7
[75.75 , 81.5]
76.3
[70.35 , 80.05]
0.5670.290.262
4+/44-62L+6C- 4.34
[0.45 , 11.3]
8.45
[1.14 , 19.2]
2.27
[1.21 , 7.67]
3.39
[0.4 , 9.85]
0.19810.341
4+/44-62L-6C+ 1.97
[1.56 , 3.44]
1.56
[0.78 , 2.94]
2.14
[0.96 , 2.77]
2.28
[1.52 , 3.06]
0.4060.5460.927
4+/44-62L-6C- 1.14
[0.25 , 1.97]
1.2
[0.59 , 1.47]
0.53
[0.45 , 0.94]
0.66
[0.23 , 1.38]
0.8620.5190.483
8+/44++62L+6C+ 16.4
[13.55 , 20.7]
19.1
[16.9 , 19.75]
21.1
[18.25 , 23.9]
18.7
[14.4 , 22.55]
0.5320.1910.447
8+/44++62L+6C- 0.21
[0.03 , 1.56]
1.69
[0.2 , 3.11]
0.39
[0.25 , 1.76]
0.48
[0.04 , 2.56]
0.170.9920.268
8+/44++62L-6C+ 7.03
[6.08 , 12.65]
7.15
[5.61 , 7.99]
6.2
[5.3 , 8.45]
9.26
[6.75 , 10.75]
0.3670.1480.741
8+/44++62L-6C- 0.65
[0.06 , 1.2]
0.73
[0.23 , 1.08]
0.44
[0.28 , 0.58]
0.4
[0.2 , 1.17]
0.6610.7670.488
8+/44-62L+6C+ 68
[48.65 , 74.35]
61.7
[50.5 , 68.55]
64.6
[58.8 , 69.5]
63.5
[54.15 , 70.25]
0.6910.5950.434
8+/44-62L+6C- 0.74
[0.3 , 7.79]
6.44
[0.73 , 16.55]
1.48
[0.6 , 5.55]
1.38
[0.19 , 9.37]
0.1640.9110.278
8+/44-62L-6C+ 2.97
[1.64 , 4.84]
2.27
[1.45 , 3.31]
1.39
[0.9 , 2.64]
3.22
[2.01 , 4.6]
0.4360.0420.408
8+/44-62L-6C- 0.25
[0.08 , 1.32]
0.42
[0.21 , 0.9]
0.24
[0.16 , 0.4]
0.27
[0.1 , 0.62]
0.4930.7050.417
Table caption: T cell subsets: Summary of total leukocyte count and T cells count
Media files
Media caption: NK cell subsets: NK/44+ boxplot with stripchart, split by sex and genotype
Media caption: Heatmap of normalised immunophenotyping data from female mutants and controls [frequency : mean of frequencies from control +/- 1.65 SD] green area represents values within mean of control, blue below, red above.
Media caption: Table caption: NK cell subsets: Frequencies of NK cell subpopulations [percentage of NK cells]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test. Number not based on the full number of male control animals.
Media caption: Heatmap of normalised immunophenotyping data from male mutants and controls [frequency : mean of frequencies from control +/- 1.65 SD] green area represents values within mean of control, blue below, red above.