Selected project
Adamts-7-KO
Graphics
Graphic caption: Flow Cytometry: B cells/B220+MHCclassII+ vs. B cells/IgD+ scatterplot
Graphic caption: Flow Cytometry: CD3+CD4+/CD44+ vs. CD3+CD8+/CD44+ scatterplot
Graphic caption: Flow Cytometry: CD45+/B cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD5-NK+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/B cells scatterplot
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: Dendrogramm hierarchical clustering
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Total IgE in Plasma: IgE boxplot with stripchart, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=15n=14n=10n=15   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 23.85 ± 2.522.92 ± 2.7220.11 ± 4.8217.68 ± 1.830.045< 0.0010.365
CD45+/CD3+CD4+ 12.01 ± 1.2911.46 ± 1.569.99 ± 38.54 ± 0.990.043< 0.0010.349
CD45+/CD3+CD8+ 9.73 ± 1.139.48 ± 1.088.64 ± 1.867.74 ± 0.890.093< 0.0010.344
CD45+/B cells 38.37 ± 4.0538.71 ± 3.9143.33 ± 4.2643.26 ± 4.930.908< 0.0010.862
CD45+/CD5-NK+ 4.04 ± 1.083.94 ± 14.15 ± 0.865.02 ± 0.910.1620.0330.075
CD45+/CD11b+Gr1+ 10.59 ± 3.5811.25 ± 2.7613.36 ± 5.511.93 ± 4.960.7440.1460.376
CD45+/NK-Gr1-CD11b+ 11.21 ± 2.0811.66 ± 1.6211.92 ± 2.7313.21 ± 2.660.1760.080.507
CD3+CD4+/CD25+ 10.91 ± 0.9a11.85 ± 1.7311.29 ± 1.3311.94 ± 1.570.0510.5450.718
CD45+/CD3+gammadeltaTCR+ 0.1 ± 0.020.09 ± 0.020.06 ± 0.030.06 ± 0.020.526< 0.0010.631
CD3+CD4+/CD62L+ 68.55 ± 6.4573.61 ± 8.4570.15 ± 11.7272.4 ± 6.10.1080.9310.533
CD3+CD4+/CD44+ 3.89 ± 1.133.82 ± 0.984.67 ± 1.394.7 ± 1.220.9550.0130.891
CD3+CD8+/CD62L+ 84.9 ± 4.7686.84 ± 4.3486.23 ± 10.0687.44 ± 2.930.3180.5380.817
CD3+CD8+/CD44+ 7.01 ± 3.016.11 ± 1.899.85 ± 3.48.62 ± 3.130.1850.0010.836
CD45+/CD5+NK+ 0.42 ± 0.110.38 ± 0.120.33 ± 0.050.36 ± 0.130.8860.0880.268
B cells/IgD+ 87.43 ± 3.9985.61 ± 4.486.9 ± 4.5485.33 ± 3.960.1480.7270.913
B cells/CD5+ 9.33 ± 1.789.85 ± 3.237.89 ± 28.46 ± 3.030.4580.0570.972
B cells/B220+MHCclassII+ 93.27 ± 2.0592.77 ± 2.2394.45 ± 1.2393.41 ± 1.730.1470.0880.611
NK+/CD11b+ 95.34 ± 1.0495.17 ± 1.0295.42 ± 0.8695.81 ± 1.040.6880.20.317
CD3+ rest 2.11 ± 0.391.98 ± 0.361.48 ± 0.281.4 ± 0.180.229< 0.0010.76
CD45+/CD3+CD4+CD25+ 1.32 ± 0.16a1.35 ± 0.211.1 ± 0.231.02 ± 0.180.618< 0.0010.319
ratio CD4:CD8 1.24 ± 0.081.21 ± 0.11.15 ± 0.151.11 ± 0.10.2820.0020.866
ratio Granulocytes:(Tcells+B cells) 0.17 ± 0.070.19 ± 0.060.22 ± 0.130.2 ± 0.110.9290.2090.574
ratio Tcells:Bcells 0.63 ± 0.10.6 ± 0.090.47 ± 0.130.41 ± 0.060.1< 0.0010.606
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=15n=14n=10n=15   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 24
[22.05 , 25.6]
22.45
[21.02 , 24.55]
19.55
[16.65 , 22.65]
17.3
[16.95 , 19]
0.3590.2430.032
CD45+/CD3+CD4+ 12.1
[10.8 , 13.05]
11.1
[10.43 , 11.97]
9.46
[7.88 , 10.88]
8.45
[7.96 , 8.97]
0.3040.3970.031
CD45+/CD3+CD8+ 9.76
[9.23 , 10.75]
9.63
[8.64 , 10.13]
8.59
[7.48 , 9.52]
7.57
[7.36 , 8.14]
0.540.1770.055
CD45+/B cells 37.3
[35.65 , 39.1]
38.35
[36.62 , 40.8]
44.85
[42.98 , 45.67]
43.4
[41.35 , 45.9]
0.3830.7340.538
CD45+/CD5-NK+ 3.9
[3.55 , 4.54]
4.25
[3.2 , 4.7]
4.19
[3.41 , 4.68]
4.95
[4.36 , 5.49]
10.0340.08
CD45+/CD11b+Gr1+ 9.55
[8.55 , 11.4]
10.75
[9.23 , 11.85]
11.6
[10.78 , 13.43]
9.54
[9.27 , 12.25]
0.3540.2010.955
CD45+/NK-Gr1-CD11b+ 11
[9.62 , 12.75]
11.55
[10.2 , 12.9]
11.45
[10.72 , 12.07]
12.9
[12 , 14.2]
0.5980.1020.1
CD3+CD4+/CD25+ 10.65a
[10.12 , 11.88]
12.15
[10.5 , 12.88]
11.4
[10.72 , 12.2]
11.6
[10.8 , 12.55]
0.0480.3740.034
CD45+/CD3+gammadeltaTCR+ 0.1
[0.09 , 0.12]
0.08
[0.08 , 0.11]
0.06
[0.04 , 0.08]
0.06
[0.05 , 0.06]
0.3110.8360.193
CD3+CD4+/CD62L+ 67.1
[62.75 , 73.1]
71.95
[67.83 , 77.92]
70.1
[69.05 , 74.83]
72.5
[68.35 , 75.55]
0.1120.7230.135
CD3+CD4+/CD44+ 3.6
[3 , 4.92]
3.74
[3.04 , 4.62]
5.11
[3.88 , 5.5]
4.65
[4.12 , 5.22]
0.9570.8170.88
CD3+CD8+/CD62L+ 84.4
[81.35 , 87.9]
87
[84.47 , 88.9]
88.25
[86.58 , 90.9]
86.7
[86.2 , 89.15]
0.2950.3590.633
CD3+CD8+/CD44+ 6.21
[4.49 , 8.65]
6.41
[4.79 , 7.53]
10.38
[7.85 , 11.75]
7.45
[6.93 , 10.23]
0.6520.2920.499
CD45+/CD5+NK+ 0.38
[0.33 , 0.48]
0.36
[0.29 , 0.46]
0.34
[0.31 , 0.36]
0.32
[0.28 , 0.38]
0.3150.9460.367
B cells/IgD+ 87.1
[85.65 , 89.25]
86.2
[84.65 , 88.12]
87.7
[82.8 , 90.62]
85.1
[82.7 , 88.8]
0.4190.4050.17
B cells/CD5+ 9.31
[8.01 , 10.7]
9.17
[7.02 , 12.7]
7.57
[6.25 , 9.35]
7.88
[6.88 , 9.29]
0.940.8490.874
B cells/B220+MHCclassII+ 92.8
[92.2 , 94.3]
93.05
[91.38 , 94.47]
94.55
[93.62 , 95.45]
93.6
[92.25 , 94.55]
0.7230.1250.267
NK+/CD11b+ 95
[94.65 , 96]
95.3
[94.25 , 95.7]
95.5
[95 , 95.85]
95.6
[95.35 , 96.15]
0.7380.3880.67
CD3+ rest 2
[1.86 , 2.37]
1.92
[1.81 , 2.17]
1.47
[1.28 , 1.54]
1.43
[1.26 , 1.51]
0.4190.7130.162
CD45+/CD3+CD4+CD25+ 1.33a
[1.24 , 1.35]
1.32
[1.19 , 1.45]
1.09
[0.92 , 1.27]
0.98
[0.92 , 1.11]
0.8040.4280.36
ratio CD4:CD8 1.25
[1.17 , 1.31]
1.18
[1.14 , 1.27]
1.13
[1.05 , 1.26]
1.1
[1.07 , 1.18]
0.3370.6330.162
ratio Granulocytes:(Tcells+B cells) 0.16
[0.14 , 0.19]
0.17
[0.16 , 0.2]
0.18
[0.16 , 0.2]
0.16
[0.14 , 0.22]
0.4140.4520.907
ratio Tcells:Bcells 0.65
[0.56 , 0.7]
0.59
[0.56 , 0.66]
0.44
[0.38 , 0.51]
0.4
[0.38 , 0.44]
0.6280.3290.128
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