Selected project
Calcr-F6
Graphics
Graphic caption: Flow Cytometry: B cells/B220+MHCclassII+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: B cells/IgD+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD4+/CD25+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD4+/CD25+ vs. CD45+/CD3+CD4+ scatterplot
Graphic caption: Flow Cytometry: CD3+CD4+/CD44+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD4+/CD44+ vs. CD3+CD8+/CD44+ scatterplot
Graphic caption: Flow Cytometry: CD3+CD8+/CD44+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/B cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD8+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/CD5-NK+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=15n=14n=15n=15   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 22.36 ± 2.7920 ± 1.714.75 ± 2.2114.81 ± 2a0.055< 0.0010.043
CD45+/CD3+CD4+ 10.77 ± 1.659.21 ± 0.946.95 ± 0.937.02 ± 0.98a0.019< 0.0010.011
CD45+/CD3+CD8+ 9.44 ± 1.148.74 ± 0.866.37 ± 1.276.36 ± 1.02a0.218< 0.0010.23
CD45+/B cells 44.08 ± 3.9944.96 ± 5.6242.19 ± 4.6943.65 ± 8.150.4440.2950.85
CD45+/CD5-NK+ 4.03 ± 0.645.9 ± 24.41 ± 0.934.38 ± 1.640.0140.1240.012
CD45+/CD11b+Gr1+ 11.77 ± 2.7812.19 ± 3.9420.2 ± 6.5819.45 ± 9.560.921< 0.0010.725
CD45+/NK-Gr1-CD11b+ 8.8 ± 1.898.8 ± 2.0511.1 ± 2.2510.87 ± 4.740.8850.0070.885
CD3+CD4+/CD25+ 4.46 ± 0.924.82 ± 1.043.79 ± 0.85.04 ± 1.07a0.0020.3660.084
CD45+/CD3+gammadeltaTCR+ 0.7 ± 0.30.67 ± 0.10.39 ± 0.160.44 ± 0.11a0.888< 0.0010.471
CD3+CD4+/CD62L+ 93.61 ± 1.6592.67 ± 1.4992.51 ± 3.0489.81 ± 4.2a0.0170.010.237
CD3+CD4+/CD44+ 0.75 ± 0.240.76 ± 0.310.57 ± 0.331.09 ± 0.56a0.010.4560.013
CD3+CD8+/CD62L+ 91.08 ± 2.0688.76 ± 2.3188.06 ± 3.488.64 ± 3.17a0.2410.0360.054
CD3+CD8+/CD44+ 5.51 ± 1.64.91 ± 1.296.56 ± 2.348.41 ± 3.31a0.296< 0.0010.045
CD45+/CD5+NK+ 0.37 ± 0.120.45 ± 0.160.33 ± 0.150.33 ± 0.130.2250.0370.301
B cells/IgD+ 83.65 ± 4.1979.85 ± 484.87 ± 3.4381.24 ± 6.340.0030.2850.944
B cells/CD5+ 5.3 ± 1.24.29 ± 0.743.95 ± 0.873.65 ± 1.160.016< 0.0010.182
B cells/B220+MHCclassII+ 95.98 ± 1.5495.51 ± 1.4496.69 ± 0.895.43 ± 1.760.0240.3940.295
NK+/CD11b+ 4.51 ± 1.174.41 ± 1.45.78 ± 3.386.43 ± 6.020.7710.0860.692
CD4/CD8 1.14 ± 0.131.06 ± 0.11.11 ± 0.161.12 ± 0.12a0.2270.6980.195
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$. \^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=15n=14n=15n=15   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 22
[20.45 , 24.45]
19.8
[18.98 , 21.65]
15.2
[12.75 , 15.65]
15.45a
[13.25 , 16.18]
0.0160.6590.437
CD45+/CD3+CD4+ 10.5
[9.4 , 11.75]
9.5
[8.43 , 9.97]
7
[6.35 , 7.25]
7.2a
[6.17 , 7.6]
0.0090.690.38
CD45+/CD3+CD8+ 9.6
[8.45 , 10.35]
8.75
[8.28 , 9.18]
6.4
[5.4 , 7.1]
6.5a
[5.75 , 7.15]
0.1250.7710.529
CD45+/B cells 43.9
[40.35 , 46.95]
43.55
[41.27 , 50.27]
41.9
[39.2 , 45.05]
43.4
[36.95 , 51.6]
0.6830.5460.481
CD45+/CD5-NK+ 4
[3.55 , 4.35]
5.3
[5.03 , 6.22]
4
[3.85 , 4.8]
4.2
[3.3 , 4.95]
< 0.0010.720.012
CD45+/CD11b+Gr1+ 11.7
[10.15 , 13.95]
11.1
[9 , 15.4]
19.8
[15.75 , 25.9]
15.2
[11.25 , 26.05]
0.9570.5880.638
CD45+/NK-Gr1-CD11b+ 8.9
[7.3 , 9.7]
9.35
[7.53 , 10.3]
10.6
[9.2 , 12.8]
10.1
[7.5 , 13.9]
0.7390.4540.505
CD3+CD4+/CD25+ 4.3
[3.9 , 5.05]
4.85
[4.42 , 5.4]
3.8
[3.5 , 4.1]
4.7a
[4.3 , 5.22]
0.315< 0.0010.003
CD45+/CD3+gammadeltaTCR+ 0.7
[0.5 , 0.75]
0.7
[0.6 , 0.7]
0.4
[0.3 , 0.45]
0.4a
[0.4 , 0.5]
0.7140.2280.44
CD3+CD4+/CD62L+ 93.8
[92.9 , 94.3]
92.65
[92.08 , 93.88]
94
[89.35 , 94.7]
91.25a
[88.92 , 91.97]
0.1750.0240.005
CD3+CD4+/CD44+ 0.8
[0.5 , 0.95]
0.8
[0.62 , 0.88]
0.5
[0.35 , 0.7]
0.95a
[0.7 , 1.4]
0.9580.0030.024
CD3+CD8+/CD62L+ 91.5
[89.45 , 92.55]
88.65
[87.6 , 90.35]
87.8
[86.9 , 90.25]
89.1a
[87.65 , 90.33]
0.0140.470.222
CD3+CD8+/CD44+ 5.3
[4.7 , 6.1]
5.1
[3.77 , 6.08]
6.5
[4.5 , 8.3]
7.05a
[5.72 , 11.47]
0.5110.1750.685
CD45+/CD5+NK+ 0.4
[0.3 , 0.45]
0.4
[0.4 , 0.57]
0.3
[0.25 , 0.35]
0.3
[0.2 , 0.4]
0.1630.8210.27
B cells/IgD+ 84.4
[80.2 , 86.8]
80.2
[76.72 , 82.1]
84.8
[83.5 , 87]
82.8
[75.75 , 85.9]
0.0320.170.006
B cells/CD5+ 5.1
[4.6 , 5.7]
4.4
[3.65 , 4.83]
3.8
[3.4 , 4.2]
3.5
[2.85 , 3.95]
0.010.2890.037
B cells/B220+MHCclassII+ 96.5
[94.8 , 97]
95.95
[94.25 , 96.35]
96.7
[96.3 , 97.25]
95.5
[95 , 96.4]
0.2210.0140.011
NK+/CD11b+ 4.2
[3.95 , 4.85]
4
[3.33 , 5.58]
4.3
[4 , 5.75]
3.8
[3.1 , 7.8]
0.6280.3610.296
CD4/CD8 1.12
[1.04 , 1.23]
1.09
[1 , 1.12]
1.11
[1 , 1.21]
1.09a
[1.03 , 1.19]
0.090.9910.216
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