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Meis1
Graphics
Graphic caption: Acoustic startle: Acoustic startle reactivity, average plot, split by sex and genotype
Graphic caption: Open Field: Distance Traveled, average plot, split by sex and genotype
Graphic caption: Open Field: Distance in the center, average plot, split by sex and genotype
Graphic caption: Open Field: Distance traveled - Total boxplot with stripchart, split by sex and genotype
Graphic caption: Open Field: Number of rears - Total boxplot with stripchart, split by sex and genotype
Graphic caption: Open Field: Number of rears, average plot, split by sex and genotype
Graphic caption: Open Field: Percent Time Spent in the Center - Total boxplot with stripchart, split by sex and genotype
Graphic caption: Open Field: Percent Time Spent in the Center, average plot, split by sex and genotype
Graphic caption: Open Field: Percent distance in the center - Total boxplot with stripchart, split by sex and genotype
Graphic caption: Prepulse inhibition: PPI grouped barplot, split by sex and genotype
Tables
Table caption: Acoustic startle: Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=15n=15n=15n=15   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
Startle amplitude - 70 116.25 ± 25.0899.97 ± 22110.63 ± 24.91113.59 ± 28.120.3090.540.144
Startle amplitude - 80 159.01 ± 40.97157.91 ± 48.04166.89 ± 48.84177.34 ± 47.910.6990.2610.632
Startle amplitude - 85 213.52 ± 36.19181.28 ± 66.51297.04 ± 98.18301.95 ± 144.040.58< 0.0010.452
Startle amplitude - 90 322.99 ± 74.33343.81 ± 156.08504.73 ± 152.87422.93 ± 139.670.385< 0.0010.146
Startle amplitude - 100 641.07 ± 214.74751.11 ± 304.291079.09 ± 295.54828.56 ± 306.170.340.0010.017
Startle amplitude - 110 764.97 ± 224.43946.65 ± 337.731203.33 ± 321.651006.66 ± 437.540.9320.0060.035
Startle amplitude - 120 755.81 ± 219.48993.51 ± 354.571180 ± 347.06988.79 ± 379.290.7870.0170.015
Startle amplitude - BN 48.71 ± 10.1244.43 ± 7.1377.14 ± 19.0670.65 ± 21.090.184< 0.0010.783
Startle amplitude - PP67 497.15 ± 195.22787.29 ± 393.72874.49 ± 228.28731.15 ± 393.420.3730.0540.01
Startle amplitude - PP69 437.66 ± 172.82719.44 ± 320.05684.76 ± 224.79676.83 ± 335.780.0560.1510.044
Startle amplitude - PP73 362.18 ± 143.89595.87 ± 329.25587.65 ± 227.93547.99 ± 274.170.1430.180.041
Startle amplitude - PP81 313.01 ± 104.7452.93 ± 232.64481.28 ± 145.8432.23 ± 174.150.3070.10.036
Prepulse inhibition - PP67 34.65 ± 16.8119.91 ± 17.4726.11 ± 15.8528.39 ± 15.510.1470.9940.05
Prepulse inhibition - PP69 41.67 ± 17.7226.35 ± 16.5741.89 ± 17.9633.01 ± 17.920.010.4510.481
Prepulse inhibition - PP73 52.36 ± 13.4840.49 ± 15.650.75 ± 16.845.55 ± 12.730.0290.6520.385
Prepulse inhibition - PP81 57.91 ± 12.553.31 ± 10.1559.42 ± 10.2754.08 ± 12.620.0980.7010.9
Prepulse inhibition - global 46.63 ± 13.8835 ± 12.2244.54 ± 13.7440.25 ± 11.220.0190.6350.272
Startle amplitude - PP2 ISI 5 346.39 ± 111.89531.54 ± 254.95567.68 ± 256.43533.49 ± 320.860.2440.0870.092
Startle amplitude - PP2 ISI 25 365.09 ± 113.85628.67 ± 303.72680.97 ± 237.81612.61 ± 327.840.1510.0290.016
Startle amplitude - PP2 ISI 100 469.26 ± 167.05764.43 ± 355.54784.67 ± 245.02703.12 ± 407.150.1850.1160.021
Prepulse inhibition - PP2 ISI 5 53.49 ± 1443.66 ± 14.9851.43 ± 22.9847.85 ± 17.280.1470.8160.496
Prepulse inhibition - PP2 ISI 25 50.51 ± 15.4635.1 ± 17.6741.61 ± 22.2639.36 ± 18.80.0730.6330.179
Prepulse inhibition - PP2 ISI 100 37.51 ± 18.9821.37 ± 13.7634.55 ± 15.4432.53 ± 16.270.0340.3320.097
Body weight HMGU ASR 21.19 ± 1.5219.72 ± 1.3927.93 ± 2.725.79 ± 2.250.001< 0.0010.529
100 * (Stl 110 - PP2) / Stl 110 41.67 ± 17.6926.35 ± 16.5741.89 ± 17.9633.01 ± 17.920.010.4510.481
Startle amplitude - 80 / Body weight HMGU ASR 2.3 ± 0.412.26 ± 0.352.75 ± 0.612.71 ± 0.70.975< 0.0010.091
Startle amplitude - 85 / Body weight HMGU ASR 5.47 ± 0.995.05 ± 0.863.98 ± 0.94.45 ± 1.220.1690.0150.666
Startle amplitude - 90 / Body weight HMGU ASR 7.52 ± 1.978.05 ± 2.535.95 ± 1.666.91 ± 1.990.8850.1130.296
Startle amplitude - 100 / Body weight HMGU ASR 10.11 ± 1.689.23 ± 3.3810.63 ± 3.2811.77 ± 5.380.8030.5250.213
Startle amplitude - 110 / Body weight HMGU ASR 15.22 ± 3.1817.43 ± 7.6717.98 ± 5.1416.51 ± 5.610.7780.5460.032
Startle amplitude - 120 / Body weight HMGU ASR 30.11 ± 9.6737.66 ± 13.3638.63 ± 10.0832.8 ± 13.290.2880.9940.056
Startle amplitude - BN / Body weight HMGU ASR 36.07 ± 10.1747.41 ± 1543.37 ± 12.1940.07 ± 19.150.1420.6380.025
Startle amplitude - PP67 / Body weight HMGU ASR 35.64 ± 9.7949.85 ± 16.1542.51 ± 12.939.45 ± 17.80.8210.0020.967
Table caption: Open Field: Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=14n=15n=15n=15   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
Distance traveled - 5 min 5235.82 ± 1410.486377.24 ± 1377.495710.09 ± 1231.415962.32 ± 1286.030.0490.9320.204
Distance traveled - 10 min 4635.17 ± 1300.915676.03 ± 1242.534863.61 ± 1414.175713.39 ± 1209.620.0070.6950.778
Distance traveled - 15 min 4466.05 ± 1504.325197.68 ± 1346.924331.66 ± 890.235112.03 ± 1227.820.0250.7380.941
Distance traveled - 20 min 4195.44 ± 1190.965025.39 ± 1194.153934.08 ± 1074.35104.09 ± 1247.020.0020.7670.582
Distance traveled - Total 18532.47 ± 4730.0322276.35 ± 4477.6218839.42 ± 3679.7921891.81 ± 4106.740.0030.9720.756
Number of rears - 5 min 21.14 ± 10.727.33 ± 7.7528.8 ± 12.5831.27 ± 6.520.0910.0250.463
Number of rears - 10 min 21.14 ± 8.6326.93 ± 8.6132.07 ± 10.8532.4 ± 9.450.2180.0020.272
Number of rears - 15 min 21.21 ± 7.9326.07 ± 7.4929.13 ± 9.8531.2 ± 9.30.1330.0060.542
Number of rears - 20 min 22.71 ± 7.8224.93 ± 8.5930 ± 12.628.93 ± 9.180.8210.030.52
Number of rears - Total 86.07 ± 29.88105.13 ± 29.32119.53 ± 39.73123.6 ± 25.530.1650.0030.366
Percent distance in the center - 5 min 27.91 ± 7.4530.61 ± 7.6926.66 ± 7.3626.66 ± 5.860.4690.1670.469
Percent distance in the center - 10 min 33.52 ± 9.1539.4 ± 8.9331.87 ± 12.3835.77 ± 6.030.0510.2860.688
Percent distance in the center - 15 min 36.44 ± 9.9240.23 ± 10.9436.61 ± 13.3137.59 ± 7.070.390.6540.612
Percent distance in the center - 20 min 42.31 ± 9.5742.37 ± 10.4835.66 ± 9.4940.92 ± 9.690.3030.1190.314
Percent distance in the center - Total 34.6 ± 7.7937.7 ± 7.6932.12 ± 8.4134.72 ± 5.250.1440.1610.897
Percent Time Spent in the Center - 5 min 22.39 ± 8.8727.75 ± 11.1625.89 ± 11.5623.21 ± 7.070.6050.840.123
Percent Time Spent in the Center - 10 min 34.01 ± 10.3537.36 ± 9.1329.29 ± 16.1732.11 ± 8.130.3040.0990.929
Percent Time Spent in the Center - 15 min 30.44 ± 10.5737.98 ± 10.1934.86 ± 18.0734.65 ± 9.980.2720.8690.246
Percent Time Spent in the Center - 20 min 37.56 ± 13.0541.2 ± 13.3133.34 ± 14.3138.72 ± 10.530.1840.3220.797
Percent Time Spent in the Center - Total 31.1 ± 7.8536.06 ± 9.0630.85 ± 11.9632.18 ± 6.540.190.3870.447
WholeArenaDis 18532.47 ± 4730.0322276.35 ± 4477.6218839.42 ± 3679.7921891.81 ± 4106.740.0030.9720.756
Whole Arena - resting time 96.5 ± 45.3109.48 ± 37.12105.63 ± 41.04106.97 ± 26.360.4720.7390.558
Whole Arena - Permanence time 1200 ± 01200 ± 01200 ± 01200 ± 0NANANA
Whole Arena - average speed 16.87 ± 4.4820.49 ± 4.2917.28 ± 3.6120.07 ± 4.010.0040.9980.702
Periphery - distance 12000.68 ± 3238.3713794.15 ± 2814.9712638.03 ± 2152.7714308.76 ± 2961.40.0220.4350.934
Periphery - resting time 74.98 ± 34.2380.53 ± 23.5179.37 ± 32.5882.56 ± 20.210.5530.6630.873
Periphery - Permanence time 826.79 ± 94.43767.17 ± 108.62829.85 ± 143.48813.93 ± 78.460.190.3850.446
Periphery - average speed 16.14 ± 4.120.35 ± 4.1217.43 ± 4.4619.52 ± 3.480.0040.8270.32
center - distance 6531.8 ± 2358.968482.21 ± 2696.196201.4 ± 2611.487583.06 ± 1795.830.010.3280.65
center - resting time 21.51 ± 17.828.94 ± 20.5926.29 ± 17.6124.38 ± 10.020.5350.980.295
center - Permanence time 373.21 ± 94.43432.83 ± 108.61370.15 ± 143.48386.06 ± 78.470.190.3850.445
center - average speed 18.7 ± 5.7821.13 ± 4.9118.48 ± 3.6721.63 ± 5.550.0380.9150.785
Latency to enter in the center 5.14 ± 4.994.51 ± 2.825.53 ± 6.635.33 ± 4.310.7440.6380.865
Number of entries in the center 273.64 ± 84.44346.6 ± 87.95247.13 ± 76.79319.2 ± 70.990.0010.2030.983
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