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Meis1
Graphics
Graphic caption: Flow Cytometry: CD3+CD4+/CD44+ vs. CD3+CD8+/CD44+ scatterplot
Graphic caption: Flow Cytometry: CD45+/B cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD8+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/B cells scatterplot
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Total IgE in Plasma: IgE boxplot with stripchart, split by sex and genotype
Graphic caption: Total IgE in Plasma: IgE boxplot, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=15n=15n=15n=15   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 21.27 ± 3.317.77 ± 2.3616.59 ± 2.0615.86 ± 2.110.002< 0.0010.036
CD45+/CD3+CD4+ 10.2 ± 1.918.37 ± 1.47.66 ± 1.177.17 ± 1.120.003< 0.0010.078
CD45+/CD3+CD8+ 8.56 ± 1.367.13 ± 1.046.61 ± 0.586.45 ± 0.820.003< 0.0010.016
CD45+/B cells 53.41 ± 3.0152.42 ± 5.0854.68 ± 5.2756.08 ± 5.950.8720.0590.354
CD45+/CD5-NK+ 3.84 ± 0.653.73 ± 1.383.8 ± 0.593.82 ± 0.60.8590.9030.763
CD45+/CD11b+Gr1+ 7.9 ± 1.749.75 ± 3.2710.52 ± 3.2510.92 ± 5.850.2610.060.466
CD45+/NK-Gr1-CD11b+ 10.08 ± 1.7211.17 ± 2.6810.97 ± 3.3110.19 ± 2.430.8230.9520.168
CD3+CD4+/CD25+ 4.9 ± 0.555.18 ± 0.955.3 ± 0.725.28 ± 0.890.5230.2320.482
CD45+/CD3+gammadeltaTCR+ 0.95 ± 0.240.84 ± 0.120.79 ± 0.240.83 ± 0.250.5230.1480.168
CD3+CD4+/CD62L+ 53.01 ± 11.8250.73 ± 10.0646.72 ± 18.9838.7 ± 8.990.1320.0090.398
CD3+CD4+/CD44+ 4.12 ± 1.084.44 ± 1.523.7 ± 0.944.03 ± 1.350.310.2010.984
CD3+CD8+/CD62L+ 67.61 ± 10.968.07 ± 8.3365.73 ± 13.5962.07 ± 9.60.5690.1630.462
CD3+CD8+/CD44+ 1.72 ± 0.611.81 ± 0.674.06 ± 2.633.53 ± 2.150.637< 0.0010.493
CD45+/CD5+NK+ 0.43 ± 0.160.38 ± 0.10.33 ± 0.090.44 ± 0.210.4880.5890.033
B cells/IgD+ 87.38 ± 3.5587.23 ± 3.0789.19 ± 2.7389.57 ± 2.210.8780.0080.723
B cells/CD5+ 2.53 ± 0.762.07 ± 0.622.38 ± 0.632.15 ± 0.660.0480.8360.51
B cells/B220+MHCclassII+ 92.74 ± 2.5792.39 ± 7.2192.46 ± 2.4292.94 ± 3.250.9550.9030.711
NK+/CD11b+ 91.23 ± 1.6790.96 ± 2.9890.18 ± 1.890.48 ± 1.530.980.1590.595
CD3+ rest 2.51 ± 0.372.27 ± 0.272.32 ± 0.662.24 ± 0.730.2530.4350.55
CD45+/CD3+CD4+CD25+ 0.5 ± 0.090.43 ± 0.080.41 ± 0.080.38 ± 0.090.0280.0020.332
ratio CD4:CD8 1.19 ± 0.11.18 ± 0.111.16 ± 0.121.12 ± 0.150.4220.1450.599
ratio Granulocytes:(Tcells+B cells) 0.11 ± 0.030.14 ± 0.050.15 ± 0.060.16 ± 0.120.2850.0760.603
ratio Tcells:Bcells 0.4 ± 0.080.34 ± 0.060.31 ± 0.040.29 ± 0.040.008< 0.0010.18
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=15n=15n=15n=15   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 22.6
[20.2 , 23.2]
17.7
[16 , 18.65]
16.9
[14.7 , 18.05]
16.1
[14.45 , 17.3]
0.0010.3290.018
CD45+/CD3+CD4+ 10.7
[9.67 , 11.35]
8.33
[7.21 , 9.05]
7.79
[6.55 , 8.65]
7.3
[6.71 , 7.87]
0.0040.3450.025
CD45+/CD3+CD8+ 8.67
[8.22 , 9.46]
7.42
[6.45 , 7.64]
6.84
[6.1 , 7]
6.67
[6.08 , 6.88]
0.0010.6240.032
CD45+/B cells 53.7
[52.3 , 55]
53.9
[49.4 , 55.85]
55.9
[50.75 , 58.45]
57.1
[54.6 , 60.3]
0.7830.430.662
CD45+/CD5-NK+ 3.83
[3.33 , 4.28]
3.82
[3.12 , 4.12]
3.87
[3.5 , 4.18]
3.71
[3.42 , 4.25]
0.6610.9260.705
CD45+/CD11b+Gr1+ 7.44
[6.88 , 8.94]
9.6
[8.38 , 12.1]
9.19
[8.78 , 13.55]
9.4
[8 , 12]
0.0170.7990.22
CD45+/NK-Gr1-CD11b+ 9
[8.89 , 11.65]
11
[8.92 , 13.4]
9.98
[8.68 , 12.25]
9.26
[9.04 , 11.1]
0.290.8060.525
CD3+CD4+/CD25+ 4.84
[4.6 , 5.08]
5.13
[4.74 , 5.9]
5.33
[4.72 , 5.71]
5.31
[4.88 , 5.8]
0.23710.281
CD45+/CD3+gammadeltaTCR+ 0.92
[0.8 , 1.06]
0.82
[0.76 , 0.94]
0.73
[0.62 , 0.88]
0.81
[0.66 , 0.93]
0.2120.5320.772
CD3+CD4+/CD62L+ 55.4
[43.6 , 62.15]
50.9
[44.1 , 58.15]
40.4
[36.35 , 50.05]
38.5
[33.05 , 44.3]
0.5950.3610.312
CD3+CD4+/CD44+ 4.12
[3.38 , 4.99]
4.75
[3.52 , 4.98]
3.6
[3.05 , 4.32]
3.73
[3.06 , 4.98]
0.6160.7130.497
CD3+CD8+/CD62L+ 67.6
[61.4 , 76.35]
68.4
[63.65 , 73.15]
64.7
[58.4 , 69.65]
61.8
[55 , 70.65]
0.9910.5740.716
CD3+CD8+/CD44+ 1.77
[1.1 , 2.24]
1.66
[1.49 , 2.08]
2.91
[2.44 , 5.18]
3.29
[2.21 , 3.82]
0.8620.5470.829
CD45+/CD5+NK+ 0.41
[0.32 , 0.48]
0.39
[0.37 , 0.42]
0.31
[0.26 , 0.37]
0.4
[0.29 , 0.51]
0.5180.1340.308
B cells/IgD+ 88.1
[84.35 , 89.7]
87.5
[84.6 , 89.35]
90.1
[88.65 , 90.75]
90.1
[87.9 , 90.9]
0.9760.9590.968
B cells/CD5+ 2.45
[2.05 , 2.92]
2.16
[1.82 , 2.35]
2.22
[1.98 , 2.9]
2.01
[1.6 , 2.82]
0.1160.2810.082
B cells/B220+MHCclassII+ 93.3
[92.5 , 94.25]
93.8
[92.45 , 95.7]
93.5
[90.65 , 94.05]
93.7
[92.8 , 95.15]
0.3290.350.16
NK+/CD11b+ 91.3
[89.95 , 92.7]
91.7
[89.65 , 93.1]
90.5
[88.5 , 91.3]
91.2
[89.5 , 91.65]
0.8780.5060.772
CD3+ rest 2.4
[2.25 , 2.65]
2.19
[2.04 , 2.5]
2.11
[1.81 , 2.75]
1.9
[1.66 , 2.87]
0.0720.4430.259
CD45+/CD3+CD4+CD25+ 0.5
[0.45 , 0.54]
0.43
[0.37 , 0.45]
0.39
[0.36 , 0.47]
0.38
[0.32 , 0.46]
0.0050.3670.022
ratio CD4:CD8 1.16
[1.14 , 1.22]
1.15
[1.09 , 1.24]
1.14
[1.06 , 1.26]
1.16
[1.05 , 1.22]
0.5870.4660.473
ratio Granulocytes:(Tcells+B cells) 0.1
[0.09 , 0.12]
0.14
[0.11 , 0.17]
0.13
[0.12 , 0.2]
0.13
[0.1 , 0.16]
0.0140.8140.152
ratio Tcells:Bcells 0.4
[0.36 , 0.45]
0.34
[0.3 , 0.36]
0.31
[0.29 , 0.34]
0.28
[0.26 , 0.31]
0.0110.1820.028
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