Selected project
Ifitm1_1F4
Graphics
Graphic caption: Flow Cytometry: CD3+CD4+/CD44+ vs. CD3+CD8+/CD44+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD11b+Gr1+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of female mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of male mice, boxplot, split by genotype
Graphic caption: Total IgE in Plasma: IgE boxplot with stripchart, split by sex and genotype
Tables
Table caption: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=10n=10n=10n=10   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 50.63 ± 553.55 ± 3.3142.99 ± 645.69 ± 8.50.148< 0.0010.954
CD45+/CD3+CD4+ 27.46 ± 3.8530.06 ± 2.24a22.2 ± 3.4124.18 ± 4.340.054< 0.0010.787
CD45+/CD3+CD8+ 19.22 ± 1.7220.07 ± 1.45a16.68 ± 2.2217.24 ± 3.070.3280.0010.838
CD45+/B cells 12.01 ± 3.0813.06 ± 2.0815.06 ± 3.4914.24 ± 3.510.9080.0370.347
CD45+/CD5-NK+ 6.12 ± 0.686.47 ± 1.496.42 ± 1.27.18 ± 1.440.1660.2120.608
CD45+/CD11b+Gr1+ 22.01 ± 3.2917.79 ± 2.4223.13 ± 4.6421.53 ± 4.540.0220.0530.287
CD45+/NK-Gr1-CD11b+ 5.83 ± 1.795.23 ± 1.537.4 ± 3.656.62 ± 1.660.3540.0520.899
CD3+CD4+/CD25+ 10.32 ± 0.811.3 ± 0.96a11.46 ± 1.8110.62 ± 1.360.8690.5880.035
CD45+/CD3+gammadeltaTCR+ 0.53 ± 0.070.54 ± 0.04a0.37 ± 0.060.37 ± 0.090.814< 0.0010.61
CD3+CD4+/CD62L+ 61.46 ± 9.5358.62 ± 7.93a45.93 ± 18.4736.99 ± 15.120.185< 0.0010.488
CD3+CD4+/CD44+ 64.94 ± 3.859.96 ± 2.92a62.26 ± 5.3161.74 ± 3.030.0350.7230.084
CD3+CD8+/CD62L+ 76.7 ± 7.173.7 ± 7.12a62.19 ± 17.5753.06 ± 15.60.152< 0.0010.464
CD3+CD8+/CD44+ 57.82 ± 4.6452.86 ± 3.04a58.12 ± 5.0857.38 ± 3.740.0430.0840.128
CD45+/CD5+NK+ 1.15 ± 0.151.09 ± 0.120.94 ± 0.111.04 ± 0.170.6680.0070.074
B cells/IgD+ 80.68 ± 3.0480.82 ± 2.475.99 ± 5.3272.04 ± 3.40.112< 0.0010.089
B cells/CD5+ 3.85 ± 0.543.87 ± 0.653.1 ± 0.753.32 ± 0.990.6060.010.672
B cells/B220+MHCclassII+ 85.59 ± 1.9985.92 ± 1.7180.38 ± 3.4478.49 ± 2.660.338< 0.0010.175
NK+/CD11b+ 72.71 ± 4.1872.29 ± 3.2864.62 ± 4.2764.45 ± 5.130.828< 0.0010.927
CD4/CD8 1.43 ± 0.111.5 ± 0.11a1.34 ± 0.141.41 ± 0.170.0870.0420.99
Table caption: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$. \^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=10n=10n=10n=10   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 50.85
[48.65 , 53.9]
54.05
[51.88 , 55.83]
40.75
[38.83 , 47.5]
46.65
[38.65 , 50.6]
0.2560.6840.28
CD45+/CD3+CD4+ 28.2
[24.9 , 29.75]
30.23a
[29.38 , 31.39]
20.85
[19.42 , 25.34]
25.43
[20.39 , 26.69]
0.0790.3930.127
CD45+/CD3+CD8+ 19.4
[18.85 , 20.1]
19.68a
[19.04 , 20.73]
16.78
[15.1 , 18.09]
17.38
[14.8 , 19.87]
0.4840.6840.369
CD45+/B cells 10.85
[10.12 , 13.6]
13.2
[11.5 , 14.8]
13.85
[13.07 , 15.47]
15.05
[13.05 , 16.7]
0.2250.8530.482
CD45+/CD5-NK+ 6
[5.68 , 6.6]
6.1
[5.46 , 7.33]
6.2
[5.89 , 7.25]
7.44
[6.05 , 8.29]
0.870.3250.38
CD45+/CD11b+Gr1+ 22.7
[20.07 , 24.27]
16.6
[16.15 , 20.2]
21.6
[19.8 , 26.73]
22.2
[18.6 , 23.12]
0.0110.630.034
CD45+/NK-Gr1-CD11b+ 5.72
[5.38 , 6.76]
4.95
[3.9 , 6.3]
6.62
[5.63 , 7.63]
6.44
[5.38 , 7.74]
0.4940.9280.569
CD3+CD4+/CD25+ 10.4
[9.82 , 10.6]
11.2a
[10.8 , 12]
12.05
[11.22 , 12.57]
10.7
[10.62 , 11.1]
0.0160.0780.797
CD45+/CD3+gammadeltaTCR+ 0.54
[0.5 , 0.58]
0.53a
[0.52 , 0.55]
0.38
[0.34 , 0.4]
0.36
[0.33 , 0.37]
0.7950.4690.95
CD3+CD4+/CD62L+ 62.45
[61.2 , 64.33]
58.1a
[55.8 , 58.9]
45.9
[27.48 , 64.65]
33.15
[25.32 , 48.55]
0.0990.280.083
CD3+CD4+/CD44+ 65.9
[61.9 , 68.2]
59.9a
[57 , 62.5]
62.45
[60.95 , 65.25]
62.45
[61.17 , 63.27]
0.0130.6430.035
CD3+CD8+/CD62L+ 75.65
[74.67 , 82.22]
74.2a
[72.7 , 75.2]
62.15
[44.3 , 80.03]
50.5
[45.4 , 60.02]
0.2340.4680.132
CD3+CD8+/CD44+ 57.55
[55.15 , 60.9]
53.4a
[51.9 , 55.1]
58.4
[55.55 , 61.52]
59.05
[54.5 , 60.27]
0.0280.6970.091
CD45+/CD5+NK+ 1.12
[1.02 , 1.27]
1.12
[0.98 , 1.18]
0.94
[0.85 , 1.01]
1.01
[0.9 , 1.16]
0.3610.1590.654
B cells/IgD+ 81.45
[78.92 , 83.25]
80.1
[79.03 , 82.8]
77.95
[72.95 , 78.92]
71.8
[68.83 , 74.85]
0.9870.0890.286
B cells/CD5+ 3.96
[3.56 , 4.16]
3.93
[3.29 , 4.36]
3.31
[2.49 , 3.61]
2.98
[2.75 , 3.6]
0.9270.8530.846
B cells/B220+MHCclassII+ 85.4
[84.5 , 87.17]
86.6
[85.53 , 87.1]
81.05
[77.08 , 83.5]
78.65
[77.28 , 80.3]
0.6680.3420.733
NK+/CD11b+ 74
[70.47 , 75.17]
72.45
[69.6 , 74.67]
63.4
[62.05 , 64.95]
64.7
[61.4 , 67.9]
0.6170.8530.92
CD4/CD8 1.46
[1.33 , 1.51]
1.51a
[1.44 , 1.56]
1.39
[1.24 , 1.43]
1.4
[1.28 , 1.52]
0.1620.3420.111
Table caption: Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=10n=10n=10n=10   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 50.63 ± 553.55 ± 3.3142.99 ± 645.69 ± 8.50.148< 0.0010.954
CD45+/CD3+CD4+ 27.46 ± 3.8530.06 ± 2.24a22.2 ± 3.4124.18 ± 4.340.054< 0.0010.787
CD45+/CD3+CD8+ 19.22 ± 1.7220.07 ± 1.45a16.68 ± 2.2217.24 ± 3.070.3280.0010.838
CD45+/B cells 12.01 ± 3.0813.06 ± 2.0815.06 ± 3.4914.24 ± 3.510.9080.0370.347
CD45+/CD5-NK+ 6.12 ± 0.686.47 ± 1.496.42 ± 1.27.18 ± 1.440.1660.2120.608
CD45+/CD11b+Gr1+ 22.01 ± 3.2917.79 ± 2.4223.13 ± 4.6421.53 ± 4.540.0220.0530.287
CD45+/NK-Gr1-CD11b+ 5.83 ± 1.795.23 ± 1.537.4 ± 3.656.62 ± 1.660.3540.0520.899
CD3+CD4+/CD25+ 10.32 ± 0.811.3 ± 0.96a11.46 ± 1.8110.62 ± 1.360.8690.5880.035
CD45+/CD3+gammadeltaTCR+ 0.53 ± 0.070.54 ± 0.04a0.37 ± 0.060.37 ± 0.090.814< 0.0010.61
CD3+CD4+/CD62L+ 61.46 ± 9.5358.62 ± 7.93a45.93 ± 18.4736.99 ± 15.120.185< 0.0010.488
CD3+CD4+/CD44+ 64.94 ± 3.859.96 ± 2.92a62.26 ± 5.3161.74 ± 3.030.0350.7230.084
CD3+CD8+/CD62L+ 76.7 ± 7.173.7 ± 7.12a62.19 ± 17.5753.06 ± 15.60.152< 0.0010.464
CD3+CD8+/CD44+ 57.82 ± 4.6452.86 ± 3.04a58.12 ± 5.0857.38 ± 3.740.0430.0840.128
CD45+/CD5+NK+ 1.15 ± 0.151.09 ± 0.120.94 ± 0.111.04 ± 0.170.6680.0070.074
B cells/IgD+ 80.68 ± 3.0480.82 ± 2.475.99 ± 5.3272.04 ± 3.40.112< 0.0010.089
B cells/CD5+ 3.85 ± 0.543.87 ± 0.653.1 ± 0.753.32 ± 0.990.6060.010.672
B cells/B220+MHCclassII+ 85.59 ± 1.9985.92 ± 1.7180.38 ± 3.4478.49 ± 2.660.338< 0.0010.175
NK+/CD11b+ 72.71 ± 4.1872.29 ± 3.2864.62 ± 4.2764.45 ± 5.130.828< 0.0010.927
CD3+ rest 3.95 ± 1.273.54 ± 0.61a4.11 ± 1.824.27 ± 2.030.8080.3810.571
Table caption: Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=10n=10n=10n=10   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 50.85
[48.65 , 53.9]
54.05
[51.88 , 55.83]
40.75
[38.83 , 47.5]
46.65
[38.65 , 50.6]
0.2560.6840.28
CD45+/CD3+CD4+ 28.2
[24.9 , 29.75]
30.23a
[29.38 , 31.39]
20.85
[19.42 , 25.34]
25.43
[20.39 , 26.69]
0.0790.3930.127
CD45+/CD3+CD8+ 19.4
[18.85 , 20.1]
19.68a
[19.04 , 20.73]
16.78
[15.1 , 18.09]
17.38
[14.8 , 19.87]
0.4840.6840.369
CD45+/B cells 10.85
[10.12 , 13.6]
13.2
[11.5 , 14.8]
13.85
[13.07 , 15.47]
15.05
[13.05 , 16.7]
0.2250.8530.482
CD45+/CD5-NK+ 6
[5.68 , 6.6]
6.1
[5.46 , 7.33]
6.2
[5.89 , 7.25]
7.44
[6.05 , 8.29]
0.870.3250.38
CD45+/CD11b+Gr1+ 22.7
[20.07 , 24.27]
16.6
[16.15 , 20.2]
21.6
[19.8 , 26.73]
22.2
[18.6 , 23.12]
0.0110.630.034
CD45+/NK-Gr1-CD11b+ 5.72
[5.38 , 6.76]
4.95
[3.9 , 6.3]
6.62
[5.63 , 7.63]
6.44
[5.38 , 7.74]
0.4940.9280.569
CD3+CD4+/CD25+ 10.4
[9.82 , 10.6]
11.2a
[10.8 , 12]
12.05
[11.22 , 12.57]
10.7
[10.62 , 11.1]
0.0160.0780.797
CD45+/CD3+gammadeltaTCR+ 0.54
[0.5 , 0.58]
0.53a
[0.52 , 0.55]
0.38
[0.34 , 0.4]
0.36
[0.33 , 0.37]
0.7950.4690.95
CD3+CD4+/CD62L+ 62.45
[61.2 , 64.33]
58.1a
[55.8 , 58.9]
45.9
[27.48 , 64.65]
33.15
[25.32 , 48.55]
0.0990.280.083
CD3+CD4+/CD44+ 65.9
[61.9 , 68.2]
59.9a
[57 , 62.5]
62.45
[60.95 , 65.25]
62.45
[61.17 , 63.27]
0.0130.6430.035
CD3+CD8+/CD62L+ 75.65
[74.67 , 82.22]
74.2a
[72.7 , 75.2]
62.15
[44.3 , 80.03]
50.5
[45.4 , 60.02]
0.2340.4680.132
CD3+CD8+/CD44+ 57.55
[55.15 , 60.9]
53.4a
[51.9 , 55.1]
58.4
[55.55 , 61.52]
59.05
[54.5 , 60.27]
0.0280.6970.091
CD45+/CD5+NK+ 1.12
[1.02 , 1.27]
1.12
[0.98 , 1.18]
0.94
[0.85 , 1.01]
1.01
[0.9 , 1.16]
0.3610.1590.654
B cells/IgD+ 81.45
[78.92 , 83.25]
80.1
[79.03 , 82.8]
77.95
[72.95 , 78.92]
71.8
[68.83 , 74.85]
0.9870.0890.286
B cells/CD5+ 3.96
[3.56 , 4.16]
3.93
[3.29 , 4.36]
3.31
[2.49 , 3.61]
2.98
[2.75 , 3.6]
0.9270.8530.846
B cells/B220+MHCclassII+ 85.4
[84.5 , 87.17]
86.6
[85.53 , 87.1]
81.05
[77.08 , 83.5]
78.65
[77.28 , 80.3]
0.6680.3420.733
NK+/CD11b+ 74
[70.47 , 75.17]
72.45
[69.6 , 74.67]
63.4
[62.05 , 64.95]
64.7
[61.4 , 67.9]
0.6170.8530.92
CD3+ rest 3.65
[3.02 , 4.82]
3.6a
[3 , 3.93]
3.58
[2.63 , 5.37]
3.82
[3.39 , 4.54]
0.9050.6990.797
Media files
No records found.