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VCP KI
Graphics
Graphic caption: Flow Cytometry: CD3+CD4+/CD62L+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD8+/CD62L+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/B cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of female mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of male mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Rheumatoid factor strip chart with means, split by sex and genotype
Graphic caption: Immunglobulins: anti DNA antibodies strip chart with means, split by sex and genotype
Graphic caption: Main leukocyte populations: CD45+/B-2cells boxplot with stripchart, split by sex and genotype
Graphic caption: Main leukocyte populations: CD45+/CD11b+Ly6G+ boxplot with stripchart, split by sex and genotype
Graphic caption: Main leukocyte populations: Frequencies of main leukocyte populations of female mice, boxplot, split by genotype
Graphic caption: Main leukocyte populations: Frequencies of main leukocyte populations of male mice, boxplot, split by genotype
Graphic caption: Main leukocyte populations: Leukocytes pie chart, split by sex and genotype
Graphic caption: T cell subsets: CD4+/Ly6C+ boxplot with stripchart, split by sex and genotype
Graphic caption: T cell subsets: CD8+/Ly6C+ boxplot with stripchart, split by sex and genotype
Graphic caption: T cell subsets: T cell subpopulations pie chart, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=10n=5n=11n=13   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 19.45
[17.6 , 20.9]
17.4
[16.7 , 20.9]
15.8
[15.05 , 16.7]
17.1
[15.2 , 18.6]
0.6550.310.884
CD45+/CD3+CD4+ 10.35
[8.99 , 10.72]
10.5
[7.36 , 10.8]
8.54
[8.29 , 8.66]
9.92
[8.47 , 10.6]
0.9260.3920.764
CD45+/CD3+CD8+ 8.17
[6.97 , 8.4]
7.6
[5.97 , 8.16]
6.32
[5.55 , 6.65]
6.42
[5.77 , 7.04]
0.3710.7870.325
CD45+/B cells 38.65
[33.65 , 40.77]
32.5
[23.1 , 43.1]
50.5
[46.2 , 53.6]
44.7
[31.3 , 45.9]
0.6790.0230.226
CD45+/CD5-NK+ 1.15
[0.87 , 1.41]
1.33
[0.94 , 1.96]
1.05
[0.96 , 1.18]
0.85
[0.83 , 0.9]
0.4220.1540.447
CD45+/CD11b+Gr1+ 13.45
[12.78 , 15.62]
25.5
[14 , 26.8]
13.7
[12.5 , 14.75]
15.6
[13.8 , 27.3]
0.1560.090.033
CD45+/NK-Gr1-CD11b+ 13.85
[13 , 17.15]
14.4
[12.7 , 16.6]
12.7
[11.65 , 14.05]
14.1
[11.2 , 17.9]
0.9290.5210.851
CD3+CD4+/CD25+ 5.54
[5.1 , 6.49]
5.09
[4.96 , 6.13]
5.86
[5.34 , 7.75]
6.59
[6.36 , 8.73]
0.5940.3030.364
CD45+/CD3+gammadeltaTCR+ 0.59
[0.44 , 0.76]
0.44
[0.41 , 0.45]
0.35
[0.25 , 0.56]
0.41
[0.25 , 0.5]
0.1560.8980.26
CD3+CD4+/CD62L+ 88
[85.85 , 88.17]
78
[74.9 , 88.5]
87.7
[81.7 , 90.7]
85.8
[81.7 , 89.1]
0.4220.5590.2
CD3+CD4+/CD44+ 7.99
[6.93 , 10.15]
10.4
[7.28 , 16.1]
9.15
[7.37 , 10.36]
10.7
[6.33 , 11.4]
0.3710.5210.243
CD3+CD8+/CD62L+ 93.9
[91.92 , 95.15]
85.3
[82.2 , 93.8]
95
[90.8 , 96.55]
93.7
[90.6 , 94.5]
0.1370.5590.19
CD3+CD8+/CD44+ 13.65
[12.57 , 16.12]
16.9
[14 , 25.8]
24.1
[19.05 , 25.95]
19.8
[17.8 , 25]
0.0940.6380.11
CD45+/CD5+NK+ 0.84
[0.64 , 1.03]
0.88
[0.69 , 1.18]
0.79
[0.62 , 0.83]
0.63
[0.54 , 0.69]
0.5310.3530.591
B cells/IgD+ 90.25
[89.05 , 91.28]
84.8
[81.7 , 89.2]
94.7
[93.5 , 95]
93
[92.2 , 93.4]
0.1650.0530.621
B cells/CD5+ 1.24
[1.08 , 1.56]
1.52
[1.07 , 2.8]
0.88
[0.72 , 1.15]
1.22
[0.94 , 1.48]
0.5940.0960.248
B cells/B220+MHCclassII+ 97.95
[97.72 , 98.08]
98.3
[97.8 , 98.8]
98.9
[98.05 , 99.15]
98.8
[98.5 , 99.4]
0.3560.540.084
NK+/CD11b+ 87.9
[86.83 , 90.1]
89.9
[88.6 , 92.1]
88.7
[87.5 , 89.65]
90.2
[89 , 91.3]
0.3710.1020.054
CD3+ rest 1.4
[1.23 , 1.66]
1.45
[1.24 , 1.74]
1.24
[1.1 , 1.25]
1
[0.88 , 1.16]
0.70.0360.027
CD45+/CD3+CD4+CD25+ 0.57
[0.52 , 0.6]
0.53
[0.35 , 0.57]
0.52
[0.45 , 0.69]
0.67
[0.54 , 0.89]
0.440.1860.308
ratio CD4:CD8 1.31
[1.21 , 1.36]
1.41
[1.25 , 1.58]
1.48
[1.34 , 1.54]
1.51
[1.44 , 1.59]
0.4960.2110.023
ratio Granulocytes:(Tcells+B cells) 0.24
[0.22 , 0.3]
0.5
[0.22 , 0.75]
0.2
[0.18 , 0.23]
0.25
[0.22 , 0.55]
0.3550.0360.049
ratio Tcells:Bcells 0.5
[0.47 , 0.57]
0.5
[0.46 , 0.64]
0.32
[0.28 , 0.36]
0.37
[0.33 , 0.62]
0.8810.1450.49
Table caption: T cell subsets: Summary of total leukocyte count and T cells count
Media files
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