Selected project
KTA041
Graphics
Graphic caption: Flow Cytometry: CD3+CD4+/CD44+ vs. CD3+CD8+/CD44+ scatterplot
Graphic caption: Flow Cytometry: CD3+CD4+/CD62L+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD3+CD8+/CD62L+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/B cells boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/B cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD3+CD4+ vs. CD45+/CD3+CD8+ scatterplot
Graphic caption: Flow Cytometry: CD45+/CD5-NK+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/NK-Gr1-CD11b+ boxplot with stripchart, split by sex and genotype
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/B cells scatterplot
Graphic caption: Flow Cytometry: CD45+/T cells vs. CD45+/CD11b+Gr1+ scatterplot
Graphic caption: Flow Cytometry: Dendrogramm hierarchical clustering
Graphic caption: Flow Cytometry: FACS pie chart, split by sex and genotype
Graphic caption: Flow Cytometry: NK+/CD11b+ boxplot with stripchart, split by sex and genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of female mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Concentration in blood plasma of male mice, boxplot, split by genotype
Graphic caption: Immunglobulins: Ig G1 boxplot with stripchart, split by sex and genotype
Graphic caption: Immunglobulins: Ig G3 boxplot with stripchart, split by sex and genotype
Graphic caption: Total IgE in Plasma: IgE boxplot with stripchart, split by sex and genotype
Tables
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Means, standard deviation and p-values calculated by a linear model
femalemaleLinear modelLinear modelLinear model
 controlmutantcontrolmutantgenotypesexgenotype:sex
 n=15n=13n=15n=15   
 mean ± sdmean ± sdmean ± sdmean ± sdp-valuep-valuep-value
CD45+/T cells 35.32 ± 3.235.63 ± 2.4829.73 ± 2.8130.37 ± 2.190.507< 0.0010.818
CD45+/CD3+CD4+ 22.29 ± 2.1322.62 ± 1.5319.42 ± 2.0719.91 ± 1.570.408< 0.0010.872
CD45+/CD3+CD8+ 11.62 ± 1.1211.65 ± 1.189.33 ± 0.89.41 ± 0.790.811< 0.0010.926
CD45+/B cells 23.89 ± 2.9221.35 ± 1.7325.94 ± 3.5824.79 ± 2.160.013< 0.0010.338
CD45+/CD5-NK+ 6.22 ± 1.216.13 ± 1.784.5 ± 1.045.23 ± 0.730.333< 0.0010.209
CD45+/CD11b+Gr1+ 23.67 ± 3.9626.55 ± 3.7729.59 ± 3.0630.67 ± 3.450.04< 0.0010.342
CD45+/NK-Gr1-CD11b+ 5.22 ± 0.664.57 ± 0.835.55 ± 1.474.62 ± 0.590.0030.4540.576
CD3+CD4+/CD25+ 3.48 ± 0.563.26 ± 0.283.22 ± 0.43.17 ± 0.360.2260.1180.449
CD45+/CD3+gammadeltaTCR+ 1.5 ± 0.511.59 ± 0.410.95 ± 0.291.11 ± 0.40.243< 0.0010.76
CD3+CD4+/CD62L+ 81.37 ± 9.2973.83 ± 8.9882.91 ± 3.8576.99 ± 7.030.0010.2420.686
CD3+CD4+/CD44+ 3.68 ± 13.41 ± 0.842.01 ± 0.432.01 ± 0.450.478< 0.0010.472
CD3+CD8+/CD62L+ 86.18 ± 8.7377.11 ± 9.9986.86 ± 4.8882.13 ± 7.670.0020.1790.305
CD3+CD8+/CD44+ 5.01 ± 1.684.87 ± 1.773.75 ± 1.123.68 ± 0.850.7660.0010.921
CD45+/CD5+NK+ 0.3 ± 0.10.32 ± 0.130.23 ± 0.090.25 ± 0.070.4840.0070.904
B cells/IgD+ 71.54 ± 7.6576.12 ± 2.9380 ± 3.7279.71 ± 5.120.126< 0.0010.083
B cells/CD5+ 13.49 ± 2.414.61 ± 2.412.64 ± 2.6512.68 ± 2.650.3890.0420.423
B cells/B220+MHCclassII+ 77.77 ± 2.8777.41 ± 5.7373.87 ± 3.6973.42 ± 3.90.7090.0010.965
NK+/CD11b+ 82.98 ± 2.3284.89 ± 1.8271.63 ± 3.3973.96 ± 2.90.004< 0.0010.768
CD3+ rest 1.42 ± 0.261.36 ± 0.310.98 ± 0.141.05 ± 0.180.925< 0.0010.313
CD45+/CD3+CD4+CD25+ 0.78 ± 0.150.74 ± 0.070.62 ± 0.060.63 ± 0.070.538< 0.0010.336
ratio CD4:CD8 1.92 ± 0.081.96 ± 0.212.08 ± 0.142.12 ± 0.140.359< 0.0010.973
ratio Granulocytes:(Tcells+B cells) 0.4 ± 0.090.47 ± 0.090.54 ± 0.090.56 ± 0.080.067< 0.0010.333
ratio Tcells:Bcells 1.5 ± 0.231.68 ± 0.161.17 ± 0.21.24 ± 0.160.019< 0.0010.289
Table caption: Flow Cytometry: Frequencies of Leukocyte subpopulations in peripheral blood after erythrocyte lysis [percentage of all leukocytes (CD45+ cells), or corresponding parent gate, respectively]. Medians, first and third quartile and p-values calculated by a Wilcoxon rank-sum test$\^{a}$ Number not based on the full number of animals (missing values)
femalemalefemalemaleoverall
 controlmutantcontrolmutant   
 n=15n=13n=15n=15   
 median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
median
[25%, 75%]
p-valuep-valuep-value
CD45+/T cells 35.2
[33.6 , 36.65]
35.4
[33.3 , 37.8]
31
[27.75 , 31.8]
30.2
[28.8 , 32.2]
0.6740.7050.802
CD45+/CD3+CD4+ 22
[20.95 , 23.4]
22.7
[21.5 , 23.6]
20.4
[17.35 , 21.2]
19.7
[18.8 , 20.7]
0.5170.8140.651
CD45+/CD3+CD8+ 11.7
[10.9 , 11.95]
11.8
[11 , 12.5]
9.58
[8.83 , 9.77]
9.42
[9.09 , 9.92]
0.7940.9270.892
CD45+/B cells 23
[22.3 , 25.2]
20.9
[20.5 , 22.2]
26
[23.4 , 28.15]
25.3
[22.9 , 26.35]
0.0110.3830.055
CD45+/CD5-NK+ 5.92
[5.45 , 6.68]
6.31
[4.67 , 7.17]
4.22
[3.83 , 4.77]
5.22
[4.74 , 5.72]
10.0080.428
CD45+/CD11b+Gr1+ 23.9
[21.7 , 25.35]
26
[24.3 , 29.5]
29.9
[28.25 , 31.6]
31.9
[27.4 , 32.8]
0.0560.3830.065
CD45+/NK-Gr1-CD11b+ 5.17
[4.78 , 5.46]
4.19
[4.06 , 4.7]
5.25
[4.62 , 6.23]
4.68
[4.17 , 5.06]
0.0120.0790.002
CD3+CD4+/CD25+ 3.59
[3.13 , 3.82]
3.31
[3.19 , 3.36]
3.27
[3 , 3.39]
3.17
[2.84 , 3.41]
0.1390.690.199
CD45+/CD3+gammadeltaTCR+ 1.38
[1.12 , 1.76]
1.53
[1.28 , 1.72]
0.91
[0.76 , 1.08]
1.06
[0.85 , 1.22]
0.420.290.27
CD3+CD4+/CD62L+ 83
[78.45 , 86.8]
76.6
[66.7 , 79.9]
83.8
[80.7 , 84.95]
75.7
[73.5 , 82.3]
0.0310.006< 0.001
CD3+CD4+/CD44+ 3.67
[2.93 , 4.54]
3.28
[2.85 , 3.85]
1.89
[1.68 , 2.24]
2.17
[1.74 , 2.32]
0.4190.690.766
CD3+CD8+/CD62L+ 87.1
[82.35 , 92.25]
77.2
[68.2 , 84.3]
87.9
[84.8 , 89.85]
81.3
[79.2 , 87.15]
0.0230.0540.002
CD3+CD8+/CD44+ 4.9
[3.69 , 6.25]
5.2
[3.82 , 5.83]
3.7
[3.04 , 4.75]
3.88
[3.14 , 4.24]
0.9640.8940.802
CD45+/CD5+NK+ 0.29
[0.23 , 0.38]
0.32
[0.23 , 0.37]
0.22
[0.18 , 0.24]
0.24
[0.2 , 0.28]
0.8290.4060.607
B cells/IgD+ 72.5
[68.2 , 76.9]
75.9
[74.6 , 76.7]
78.6
[78 , 83.05]
81
[78.45 , 83.25]
0.0580.830.301
B cells/CD5+ 12.7
[12.05 , 14.75]
14.4
[12.7 , 15.5]
11.9
[10.4 , 14.1]
12.2
[11.2 , 14.1]
0.2390.8460.393
B cells/B220+MHCclassII+ 78
[76.35 , 79.45]
77.9
[76.4 , 80.7]
74.2
[70.1 , 76.65]
72.5
[70.45 , 75.8]
0.8290.910.844
NK+/CD11b+ 83.8
[82.3 , 84.4]
85.1
[84.7 , 85.6]
71.2
[69.85 , 73.2]
75.1
[72.45 , 75.6]
0.0120.0260.15
CD3+ rest 1.4
[1.2 , 1.6]
1.4
[1.2 , 1.5]
1.03
[0.88 , 1.08]
1.1
[0.94 , 1.13]
0.7230.2120.844
CD45+/CD3+CD4+CD25+ 0.79
[0.68 , 0.86]
0.73
[0.71 , 0.78]
0.62
[0.58 , 0.67]
0.63
[0.6 , 0.65]
0.3630.7130.994
ratio CD4:CD8 1.94
[1.88 , 1.97]
1.93
[1.82 , 2.02]
2.08
[2.01 , 2.17]
2.09
[2.05 , 2.17]
0.9010.6020.392
ratio Granulocytes:(Tcells+B cells) 0.41
[0.36 , 0.44]
0.47
[0.41 , 0.55]
0.52
[0.5 , 0.56]
0.57
[0.49 , 0.6]
0.10.5450.085
ratio Tcells:Bcells 1.48
[1.32 , 1.68]
1.59
[1.55 , 1.83]
1.21
[1.01 , 1.3]
1.26
[1.09 , 1.36]
0.040.3720.159
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